B8F7G0 (KTHY_HAEPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	HAPS_1742

Organism

Haemophilus parasuis serovar 5 (strain SH0165) [Complete proteome] [HAMAP]

Taxonomic identifier

557723 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus parasuis

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Thymidylate kinase HAMAP-Rule MF_00165		PRO_1000123578
Regions
	Nucleotide binding	10 – 17	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B8F7G0 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 3E21773E4C6596B2	FASTA	208	22,831
	10 20 30 40 50 60 MRGKFIVIEG LEGAGKSNAQ RIVSETLAAH GIEFITTREP GGTPIAEALR NLWKEGEDGE 70 80 90 100 110 120 HTTDKAEVLM IYAARIQLVE TVIEPALASG KWVVGDRHNM SSQAYQGGGR GLAELVDEVG 130 140 150 160 170 180 SAILGDFEPD FTIYLDIEPS IGLERARGRG ALDRIEQLDI DFFHRTRERY VSLVKDNPKA 190 200 VLINAEPAIE QVSADIQQAV EIFLTSEK

References

[1]	"Complete genome sequence of Haemophilus parasuis SH0165." Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R., Jin M., Jin Q., Chen H. J. Bacteriol. 191:1359-1360(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SH0165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001321 Genomic DNA. Translation: ACL33262.1.
RefSeq	YP_002476210.1. NC_011852.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	557723.HAPS_1742.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL33262; ACL33262; HAPS_1742.
GeneID	7277655.
KEGG	hap:HAPS_1742.
PATRIC	20195799. VBIHaePar127548_1722.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0125.
HOGENOM	HOG000229078.
KO	K00943.
OMA	ITLEGPE.
Enzyme and pathway databases
BioCyc	HPAR557723:GH24-1742-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
PANTHER	PTHR10344. PTHR10344. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_HAEPS

Accession

Primary (citable) accession number: B8F7G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	May 29, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program