B8F6B1 (LPXA_HAEPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Short name=UDP-N-acetylglucosamine acyltransferase
EC=2.3.1.129

Gene names

Name:	lpxA
Ordered Locus Names:	HAPS_1270

Organism

Haemophilus parasuis serovar 5 (strain SH0165) [Complete proteome] [HAMAP]

Taxonomic identifier

557723 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus parasuis

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine. HAMAP-Rule MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP-Rule MF_00387
Subunit structure	Homotrimer By similarity. HAMAP-Rule MF_00387
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP-Rule MF_00387		PRO_1000134386

Sequences

	Sequence		Length	Mass (Da)
	B8F6B1 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 828A5F941E4D5757	FASTA	264	28,641
	10 20 30 40 50 60 MPLIDASAKI HPTALIEEGA KIGANVEIGA FCVIGKDVRI GAGTKIHSHV VIQGDTEIGE 70 80 90 100 110 120 DNQIFQFASI GEINQDLKYQ GEPTKTIIGH RNRIRESVTI HRGTVQGGGV TRVGNDNLFM 130 140 150 160 170 180 INCHIAHDCS IGNRCIIANN GTLAGHVTLD DFVIVGGMSA IHQFVVVGSH VMLGGGSMVS 190 200 210 220 230 240 QDVPPYIMAQ GNHAQPFGVN LEGLKRRGFE KATMHAIRNV YKLIYRSGKT LEEAIPEIEQ 250 260 YAKTEAAVSL FLDFFKRSTR GIIR

References

[1]	"Complete genome sequence of Haemophilus parasuis SH0165." Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R., Jin M., Jin Q., Chen H. J. Bacteriol. 191:1359-1360(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SH0165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001321 Genomic DNA. Translation: ACL32863.1.
RefSeq	YP_002475811.1. NC_011852.1.
3D structure databases
ProteinModelPortal	B8F6B1.
SMR	B8F6B1. Positions 3-264.
ModBase	Search...
Protein-protein interaction databases
STRING	557723.HAPS_1270.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL32863; ACL32863; HAPS_1270.
GeneID	7278063.
KEGG	hap:HAPS_1270.
PATRIC	20194819. VBIHaePar127548_1254.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1043.
HOGENOM	HOG000294326.
KO	K00677.
OMA	REFCTFN.
Enzyme and pathway databases
BioCyc	HPAR557723:GH24-1270-MONOMER.
UniPathway	UPA00359; UER00477.
Family and domain databases
HAMAP	MF_00387. LpxA.
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR010137. Lipid_A_LpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
Pfam	PF00132. Hexapep. 3 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. lipid_A_lpxA. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXA_HAEPS

Accession

Primary (citable) accession number: B8F6B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	May 29, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program