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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Haemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateUniRule annotation1
Binding sitei68SubstrateUniRule annotation1
Binding sitei127SubstrateUniRule annotation1
Sitei168Important for catalytic activityUniRule annotation1
Active sitei170Proton donor/acceptorUniRule annotation1
Active sitei242NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciHPAR557723:G1GUF-1005-MONOMER
UniPathwayiUPA00544

Protein family/group databases

CAZyiGH3 Glycoside Hydrolase Family 3

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:HAPS_1013
OrganismiHaemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeGlaesserella
Proteomesi
  • UP000006743 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001336651 – 340Beta-hexosaminidaseAdd BLAST340

Interactioni

Protein-protein interaction databases

STRINGi557723.HAPS_1013

Structurei

3D structure databases

ProteinModelPortaliB8F5N0
SMRiB8F5N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 158Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPA Bacteria
COG1472 LUCA
HOGENOMiHOG000248526
KOiK01207
OMAiHKETPRD

Family and domain databases

Gene3Di3.20.20.300, 1 hit
HAMAPiMF_00364 NagZ, 1 hit
InterProiView protein in InterPro
IPR022956 Beta_hexosaminidase_bac
IPR019800 Glyco_hydro_3_AS
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00933 Glyco_hydro_3, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00775 GLYCOSYL_HYDROL_F3, 1 hit

Sequencei

Sequence statusi: Complete.

B8F5N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLIDLAGYE LTQEEQELLE HPLVSGLILF TRNFHDKAQL QALIKSVRQR
60 70 80 90 100
VKKPLLITVD QEGGRVQRFR EGFTKLPAMQ SFLQLDRLQL AQEAGWLMSA
110 120 130 140 150
EMFALDIDLS FAPVLDLGHC SKAIGDRSFG EDVATMLPVA EAFIDGMREI
160 170 180 190 200
GMAATGKHFP GHGHVIADSH LETPFDDRPK ETIFNHDIQP FKQLIAKGKL
210 220 230 240 250
SAIMPAHVIY TQCDSQPASG SSYWLKEILR KQLQFNGVIF SDDLGMKGAG
260 270 280 290 300
FMGNYVERSE KALQAGCDLL LLCNEPDGVV QVLDNLKYQP TPTQKERYLS
310 320 330 340
LMKRKQISWS ELTASPRWQQ AHQQLATLQD QWLEWKAQNA
Length:340
Mass (Da):38,363
Last modified:March 3, 2009 - v1
Checksum:iBC39F92576C5391B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA Translation: ACL32632.1
RefSeqiWP_015939571.1, NC_011852.1

Genome annotation databases

EnsemblBacteriaiACL32632; ACL32632; HAPS_1013
GeneIDi7277081
KEGGihap:HAPS_1013
PATRICifig|557723.8.peg.1011

Similar proteinsi

Entry informationi

Entry nameiNAGZ_HAEPS
AccessioniPrimary (citable) accession number: B8F5N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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