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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi14 – 141Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi17 – 171Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi92 – 921Iron-sulfur (4Fe-4S)UniRule annotation
Binding sitei217 – 2171S-adenosyl-L-methionineUniRule annotation
Binding sitei246 – 2461S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei273 – 2731S-adenosyl-L-methionineUniRule annotation
Binding sitei319 – 3191S-adenosyl-L-methionineUniRule annotation
Active sitei346 – 3461NucleophileUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPAR557723:GH24-1012-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Synonyms:rumB
Ordered Locus Names:HAPS_1012
OrganismiHaemophilus parasuis serovar 5 (strain SH0165)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000006743 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 38938923S rRNA (uracil(747)-C(5))-methyltransferase RlmCPRO_0000414819Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557723.HAPS_1012.

Structurei

3D structure databases

ProteinModelPortaliB8F5M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SFS. Bacteria.
COG2265. LUCA.
HOGENOMiHOG000218547.
KOiK03212.
OMAiQTNSYAL.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8F5M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLNCHHFE QNRCNSCQWL HKSYTEQLAE KTSDLKRLVS PYLLQSTEFL
60 70 80 90 100
PAVTSPLAHF RNKAKMVVTG SVERPILGIL NDDGTGTDLT DCPLYPQAFT
110 120 130 140 150
PLFPILKTFI GRAGLVPYNV AKKRGELKYI LITQSQHNQS LMIRFVLRSE
160 170 180 190 200
LKRPLVEREL PMLLAQLPEK SVVSLNIQPQ HSAILEGEQE IFLTEQQVLE
210 220 230 240 250
ERFNQIPLFI RPQGFFQTNP TVASQLYHTA QEWIKERPIT QLWDLFCGVG
260 270 280 290 300
GFGLHCANTL QTNNPNVALT GIEISASAIA SATKSAQQLG LQNVKFASLD
310 320 330 340 350
SAQFALNEQG TTPDLVIVNP PRRGIGKPLA EFINQLGSPY LIYSSCNAET
360 370 380
MAKDFASLSH YELKKVQLFD MFPHTAHYEV LTFLVNKII
Length:389
Mass (Da):43,749
Last modified:March 3, 2009 - v1
Checksum:i9A3ACE445A980D5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA. Translation: ACL32631.1.
RefSeqiWP_015939570.1. NC_011852.1.

Genome annotation databases

EnsemblBacteriaiACL32631; ACL32631; HAPS_1012.
GeneIDi7277080.
KEGGihap:HAPS_1012.
PATRICi20194307. VBIHaePar127548_1010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA. Translation: ACL32631.1.
RefSeqiWP_015939570.1. NC_011852.1.

3D structure databases

ProteinModelPortaliB8F5M9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi557723.HAPS_1012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL32631; ACL32631; HAPS_1012.
GeneIDi7277080.
KEGGihap:HAPS_1012.
PATRICi20194307. VBIHaePar127548_1010.

Phylogenomic databases

eggNOGiENOG4107SFS. Bacteria.
COG2265. LUCA.
HOGENOMiHOG000218547.
KOiK03212.
OMAiQTNSYAL.

Enzyme and pathway databases

BioCyciHPAR557723:GH24-1012-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRLMC_HAEPS
AccessioniPrimary (citable) accession number: B8F5M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.