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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Haemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi14Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi17Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi92Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei217S-adenosyl-L-methionineUniRule annotation1
Binding sitei246S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei273S-adenosyl-L-methionineUniRule annotation1
Binding sitei319S-adenosyl-L-methionineUniRule annotation1
Active sitei346NucleophileUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPAR557723:G1GUF-1004-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Synonyms:rumB
Ordered Locus Names:HAPS_1012
OrganismiHaemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeGlaesserella
Proteomesi
  • UP000006743 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004148191 – 38923S rRNA (uracil(747)-C(5))-methyltransferase RlmCAdd BLAST389

Interactioni

Protein-protein interaction databases

STRINGi557723.HAPS_1012

Structurei

3D structure databases

ProteinModelPortaliB8F5M9
SMRiB8F5M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SFS Bacteria
COG2265 LUCA
HOGENOMiHOG000218547
KOiK03212
OMAiSCQWLEK

Family and domain databases

HAMAPiMF_01012 23SrRNA_methyltr_RlmC, 1 hit
InterProiView protein in InterPro
IPR011825 23SrRNA_MeTrfase_RlmC
IPR030390 MeTrfase_TrmA_AS
IPR030391 MeTrfase_TrmA_CS
IPR029063 SAM-dependent_MTases
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02085 meth_trns_rumB, 1 hit
PROSITEiView protein in PROSITE
PS51687 SAM_MT_RNA_M5U, 1 hit
PS01230 TRMA_1, 1 hit
PS01231 TRMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8F5M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLNCHHFE QNRCNSCQWL HKSYTEQLAE KTSDLKRLVS PYLLQSTEFL
60 70 80 90 100
PAVTSPLAHF RNKAKMVVTG SVERPILGIL NDDGTGTDLT DCPLYPQAFT
110 120 130 140 150
PLFPILKTFI GRAGLVPYNV AKKRGELKYI LITQSQHNQS LMIRFVLRSE
160 170 180 190 200
LKRPLVEREL PMLLAQLPEK SVVSLNIQPQ HSAILEGEQE IFLTEQQVLE
210 220 230 240 250
ERFNQIPLFI RPQGFFQTNP TVASQLYHTA QEWIKERPIT QLWDLFCGVG
260 270 280 290 300
GFGLHCANTL QTNNPNVALT GIEISASAIA SATKSAQQLG LQNVKFASLD
310 320 330 340 350
SAQFALNEQG TTPDLVIVNP PRRGIGKPLA EFINQLGSPY LIYSSCNAET
360 370 380
MAKDFASLSH YELKKVQLFD MFPHTAHYEV LTFLVNKII
Length:389
Mass (Da):43,749
Last modified:March 3, 2009 - v1
Checksum:i9A3ACE445A980D5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA Translation: ACL32631.1
RefSeqiWP_015939570.1, NC_011852.1

Genome annotation databases

EnsemblBacteriaiACL32631; ACL32631; HAPS_1012
GeneIDi7277080
KEGGihap:HAPS_1012
PATRICifig|557723.8.peg.1010

Similar proteinsi

Entry informationi

Entry nameiRLMC_HAEPS
AccessioniPrimary (citable) accession number: B8F5M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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