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B8F5K4

- MDH_HAEPS

UniProt

B8F5K4 - MDH_HAEPS

Protein

Malate dehydrogenase

Gene

mdh

Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADUniRule annotation
    Binding sitei81 – 811SubstrateUniRule annotation
    Binding sitei87 – 871SubstrateUniRule annotation
    Binding sitei94 – 941NADUniRule annotation
    Binding sitei119 – 1191SubstrateUniRule annotation
    Binding sitei153 – 1531SubstrateUniRule annotation
    Active sitei177 – 1771Proton acceptorUniRule annotation
    Binding sitei230 – 2301NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 137NADUniRule annotation
    Nucleotide bindingi117 – 1193NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciHPAR557723:GH24-981-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:HAPS_0981
    OrganismiHaemophilus parasuis serovar 5 (strain SH0165)
    Taxonomic identifieri557723 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000006743: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Malate dehydrogenasePRO_1000185078Add
    BLAST

    Proteomic databases

    PRIDEiB8F5K4.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi557723.HAPS_0981.

    Structurei

    3D structure databases

    ProteinModelPortaliB8F5K4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213792.
    KOiK00024.
    OMAiKARGVYN.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01516. Malate_dehydrog_1.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010097. Malate_DH_type1.
    IPR023958. Malate_DH_type1_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8F5K4-1 [UniParc]FASTAAdd to Basket

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    MKVAVLGAAG GIGQALALLL KLQLPAGTNL ALYDIAPVTP GVAVDVSHIP    50
    TAVKVVGYAG EDPTPALEGA NLVLISAGVA RKPGMDRSDL FNINAGIVRN 100
    LIEKVATVCP TACVGIITNP VNTTVAIAAE VLKKAGVYDK RKLFGVTSLD 150
    VLRSETFVAE LKGKDVNDVK VPVIGGHSGV TILPLLSQAF EEDKIDFTAE 200
    EVAALTKRIQ NAGTEVVEAK AGGGSATLSM AQAAARFARS VLKGLTGEQV 250
    VEYAYVEGNG EYARFFAQPV RLGLNGVEEL LPIGTLSAYE EEAVQAMIPT 300
    LKADIELGEK FVNG 314
    Length:314
    Mass (Da):32,650
    Last modified:March 3, 2009 - v1
    Checksum:i87B5D9FC2CDCBF97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001321 Genomic DNA. Translation: ACL32606.1.
    RefSeqiWP_015939552.1. NC_011852.1.
    YP_002475554.1. NC_011852.1.

    Genome annotation databases

    EnsemblBacteriaiACL32606; ACL32606; HAPS_0981.
    GeneIDi7277854.
    KEGGihap:HAPS_0981.
    PATRICi20194241. VBIHaePar127548_0981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001321 Genomic DNA. Translation: ACL32606.1 .
    RefSeqi WP_015939552.1. NC_011852.1.
    YP_002475554.1. NC_011852.1.

    3D structure databases

    ProteinModelPortali B8F5K4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557723.HAPS_0981.

    Proteomic databases

    PRIDEi B8F5K4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL32606 ; ACL32606 ; HAPS_0981 .
    GeneIDi 7277854.
    KEGGi hap:HAPS_0981.
    PATRICi 20194241. VBIHaePar127548_0981.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213792.
    KOi K00024.
    OMAi KARGVYN.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci HPAR557723:GH24-981-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01516. Malate_dehydrog_1.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010097. Malate_DH_type1.
    IPR023958. Malate_DH_type1_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Haemophilus parasuis SH0165."
      Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R., Jin M., Jin Q., Chen H.
      J. Bacteriol. 191:1359-1360(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SH0165.

    Entry informationi

    Entry nameiMDH_HAEPS
    AccessioniPrimary (citable) accession number: B8F5K4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3