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B8F5I8

- LPXB_HAEPS

UniProt

B8F5I8 - LPXB_HAEPS

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, HAPS_0965
Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHPAR557723:GH24-965-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:HAPS_0965
OrganismiHaemophilus parasuis serovar 5 (strain SH0165)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000006743: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000191487Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557723.HAPS_0965.

Structurei

3D structure databases

ProteinModelPortaliB8F5I8.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B8F5I8-1 [UniParc]FASTAAdd to Basket

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MTTSSPLIAI VAGEISGDIL GAGLIKALKV HYPNARFIGV AGEKMLKEGC    50
ETLFDMEKLA VMGLAEVVRH LPRLLKRRKQ VIDTMLALKP DIFIGIDAPD 100
FNLGVEEKLK AQGIKTIHYV SPSVWAWRQN RVHKIASATD LVLAFLPFEK 150
AFYDRFNVPC RFIGHTMADA IALQPNRQEA CRLLQLDENQ HYVAILVGSR 200
GSEVNFLSEP FLKTAQLLKA QYPDVQFLVP LVNEKRREQF EAIKAQVAPE 250
LEVITLAGNA RAAMMVAEAT LLASGTAALE AMLCKSPMVV GYKMKPLTYW 300
LAKRLVKTDY ISLPNLLANE PLVPELIQAD CSPENLAKHL SLYLSQMPED 350
VAKKNALKQR FMELHQYIQC DADAQAAQAV VDVLNRE 387
Length:387
Mass (Da):43,061
Last modified:March 3, 2009 - v1
Checksum:iAB11AC476A679460
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001321 Genomic DNA. Translation: ACL32590.1.
RefSeqiYP_002475538.1. NC_011852.1.

Genome annotation databases

EnsemblBacteriaiACL32590; ACL32590; HAPS_0965.
GeneIDi7277838.
KEGGihap:HAPS_0965.
PATRICi20194209. VBIHaePar127548_0965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001321 Genomic DNA. Translation: ACL32590.1 .
RefSeqi YP_002475538.1. NC_011852.1.

3D structure databases

ProteinModelPortali B8F5I8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 557723.HAPS_0965.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL32590 ; ACL32590 ; HAPS_0965 .
GeneIDi 7277838.
KEGGi hap:HAPS_0965.
PATRICi 20194209. VBIHaePar127548_0965.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci HPAR557723:GH24-965-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Haemophilus parasuis SH0165."
    Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R., Jin M., Jin Q., Chen H.
    J. Bacteriol. 191:1359-1360(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH0165.

Entry informationi

Entry nameiLPXB_HAEPS
AccessioniPrimary (citable) accession number: B8F5I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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