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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHPAR557723:GH24-965-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:HAPS_0965
OrganismiHaemophilus parasuis serovar 5 (strain SH0165)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000006743: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Lipid-A-disaccharide synthasePRO_1000191487Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557723.HAPS_0965.

Structurei

3D structure databases

ProteinModelPortaliB8F5I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiQPWVGLP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B8F5I8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTSSPLIAI VAGEISGDIL GAGLIKALKV HYPNARFIGV AGEKMLKEGC
60 70 80 90 100
ETLFDMEKLA VMGLAEVVRH LPRLLKRRKQ VIDTMLALKP DIFIGIDAPD
110 120 130 140 150
FNLGVEEKLK AQGIKTIHYV SPSVWAWRQN RVHKIASATD LVLAFLPFEK
160 170 180 190 200
AFYDRFNVPC RFIGHTMADA IALQPNRQEA CRLLQLDENQ HYVAILVGSR
210 220 230 240 250
GSEVNFLSEP FLKTAQLLKA QYPDVQFLVP LVNEKRREQF EAIKAQVAPE
260 270 280 290 300
LEVITLAGNA RAAMMVAEAT LLASGTAALE AMLCKSPMVV GYKMKPLTYW
310 320 330 340 350
LAKRLVKTDY ISLPNLLANE PLVPELIQAD CSPENLAKHL SLYLSQMPED
360 370 380
VAKKNALKQR FMELHQYIQC DADAQAAQAV VDVLNRE
Length:387
Mass (Da):43,061
Last modified:March 3, 2009 - v1
Checksum:iAB11AC476A679460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA. Translation: ACL32590.1.
RefSeqiWP_015939546.1. NC_011852.1.
YP_002475538.1. NC_011852.1.

Genome annotation databases

EnsemblBacteriaiACL32590; ACL32590; HAPS_0965.
GeneIDi7277838.
KEGGihap:HAPS_0965.
PATRICi20194209. VBIHaePar127548_0965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA. Translation: ACL32590.1.
RefSeqiWP_015939546.1. NC_011852.1.
YP_002475538.1. NC_011852.1.

3D structure databases

ProteinModelPortaliB8F5I8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi557723.HAPS_0965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL32590; ACL32590; HAPS_0965.
GeneIDi7277838.
KEGGihap:HAPS_0965.
PATRICi20194209. VBIHaePar127548_0965.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiQPWVGLP.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciHPAR557723:GH24-965-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Haemophilus parasuis SH0165."
    Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R., Jin M., Jin Q., Chen H.
    J. Bacteriol. 191:1359-1360(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH0165.

Entry informationi

Entry nameiLPXB_HAEPS
AccessioniPrimary (citable) accession number: B8F5I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.