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B8F5E6

- PUR5_HAEPS

UniProt

B8F5E6 - PUR5_HAEPS

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPAR557723:GH24-920-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:HAPS_0920
    OrganismiHaemophilus parasuis serovar 5 (strain SH0165)
    Taxonomic identifieri557723 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000006743: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000148283Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557723.HAPS_0920.

    Structurei

    3D structure databases

    ProteinModelPortaliB8F5E6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8F5E6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVTQLSYKD AGVDIHAGND LVERIKGDVK RTRRPEVIGG LGGFGALCAL    50
    PTKYKEPILV SGTDGVGTKL RLAIDLNKHD TIGIDLVAMC VNDLVVQGAE 100
    PLFFLDYYAT GKLDVDVASS VIKGIANGCE QSCCALVGGE TAEMPGMYHA 150
    GDYDLAGFCV GVVEKSEIID GSKVQVGDTL IALGSSGPHS NGYSLIRKVL 200
    EVSGTKPMDL LEGKPLSEHF LAPTKIYVKS VLELIKQAEV HAIAHLTGGG 250
    FWENIPRVLP ADVKAVINEA SWEWLPSFKW LQEKGNISRY EMYRTFNCGV 300
    GMVIALPEKD VETALKVLTE AGENAWVIGK IEALGSGTEQ VEIL 344
    Length:344
    Mass (Da):36,921
    Last modified:March 3, 2009 - v1
    Checksum:i8AA8F9C429CC018C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001321 Genomic DNA. Translation: ACL32548.1.
    RefSeqiYP_002475496.1. NC_011852.1.

    Genome annotation databases

    EnsemblBacteriaiACL32548; ACL32548; HAPS_0920.
    GeneIDi7277071.
    KEGGihap:HAPS_0920.
    PATRICi20194113. VBIHaePar127548_0918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001321 Genomic DNA. Translation: ACL32548.1 .
    RefSeqi YP_002475496.1. NC_011852.1.

    3D structure databases

    ProteinModelPortali B8F5E6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557723.HAPS_0920.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL32548 ; ACL32548 ; HAPS_0920 .
    GeneIDi 7277071.
    KEGGi hap:HAPS_0920.
    PATRICi 20194113. VBIHaePar127548_0918.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci HPAR557723:GH24-920-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Haemophilus parasuis SH0165."
      Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R., Jin M., Jin Q., Chen H.
      J. Bacteriol. 191:1359-1360(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SH0165.

    Entry informationi

    Entry nameiPUR5_HAEPS
    AccessioniPrimary (citable) accession number: B8F5E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3