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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Haemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi485MagnesiumUniRule annotation1
Metal bindingi491MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:HAPS_0476
OrganismiHaemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeGlaesserella
Proteomesi
  • UP000006743 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001857381 – 709Polyribonucleotide nucleotidyltransferaseAdd BLAST709

Proteomic databases

PRIDEiB8F492

Interactioni

Subunit structurei

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.UniRule annotation

Protein-protein interaction databases

STRINGi557723.HAPS_0476

Structurei

3D structure databases

ProteinModelPortaliB8F492
SMRiB8F492
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini552 – 611KHUniRule annotationAdd BLAST60
Domaini621 – 689S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

B8F492-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPIVKQFKY GQHTVTLETG AIARQATAAV MASMDDTTVF VTVVAKKEVN
60 70 80 90 100
EGQDFFPLTV DYQERTYAAG RIPGGFFKRE GRPSEGETLI ARLIDRPVRP
110 120 130 140 150
LFPEGFFNEI QVIATVVSVN PQISPDLVAM IGASAALSLS GVPFNGPIGA
160 170 180 190 200
ARVGFIDNQF VLNPTTSEQR LSRLDLVVAG TDKAVLMVES EADILTEEQM
210 220 230 240 250
LAAVVFGHEQ QQVVIENIKE FVKEAGKPRW DWVAPEPNTD LINKVKALAE
260 270 280 290 300
ARLGDAYRIT EKQARYEQID AIKADVIAQL TAEDETISSG KIVDIITALE
310 320 330 340 350
SQIVRSRIIA GEPRIDGRTV DTVRALDICT GVLPRTHGSA LFTRGETQAL
360 370 380 390 400
AVATLGTERD AQIIDELTGE KSDRFLFHYN FPPYSVGETG RIGSPKRREI
410 420 430 440 450
GHGRLAKRGV LAVMPTAEEF PYVVRVVSEI TESNGSSSMA SVCGASLALM
460 470 480 490 500
DAGVPIKAAV AGIAMGLVKE EEKFVVLSDI LGDEDHLGDM DFKVAGTREG
510 520 530 540 550
VTALQMDIKI EGITPEIMRI ALNQAKGARM HILGVMEQAI PAPRSEISDF
560 570 580 590 600
APRIHTMKID PKKIKDVIGK GGATIRALTE ETGTSIDIDD DGTVKIAATD
610 620 630 640 650
NNAAKRVMER IEEIVAEVEV NAIYKGKVTR VVDFGAFVSI LGGKEGLVHI
660 670 680 690 700
SQITDARVER VADYLSVGQD VQVKVVEIER QGRIRLTMKD LNGDATAREV

VEEIQELAE
Length:709
Mass (Da):76,998
Last modified:March 3, 2009 - v1
Checksum:i9321F834576D3A70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA Translation: ACL32144.1
RefSeqiWP_005711570.1, NC_011852.1

Genome annotation databases

EnsemblBacteriaiACL32144; ACL32144; HAPS_0476
GeneIDi7278481
KEGGihap:HAPS_0476

Similar proteinsi

Entry informationi

Entry nameiPNP_HAEPS
AccessioniPrimary (citable) accession number: B8F492
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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