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B8F472

- PYRF_HAEPS

UniProt

B8F472 - PYRF_HAEPS

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, HAPS_0456
Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Substrate By similarity
Binding sitei32 – 321Substrate By similarity
Active sitei61 – 611Proton donor By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei180 – 1801Substrate By similarity
Binding sitei189 – 1891Substrate By similarity
Binding sitei209 – 2091Substrate; via amide nitrogen By similarity
Binding sitei210 – 2101Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciHPAR557723:GH24-456-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:HAPS_0456
OrganismiHaemophilus parasuis serovar 5 (strain SH0165)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000006743: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000164572Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi557723.HAPS_0456.

Structurei

3D structure databases

ProteinModelPortaliB8F472.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 6810Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8F472-1 [UniParc]FASTAAdd to Basket

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MDNKIIVALD YETEAEALNF VDQVDPSLCR LKVGKEMFTT LGTHFVKQLQ    50
DRKFDVFLDL KYHDIPNTVA RAVRSAADLG VWMVDLHACG GLRMMETAKQ 100
ILEPYGKDAP LLIGVTVLTS MEDLDLLQIG INASPMEQVI RLAHLCQRAG 150
LDGVVCSPQE VEVLRTHCGK DFKLVTPGIR PEGSDFGDQR RVMTPKQAIE 200
IGSDYLVIGR PITQAADPLA VLKSINQSIA 230
Length:230
Mass (Da):25,373
Last modified:March 3, 2009 - v1
Checksum:i5232E3CA4E4699DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001321 Genomic DNA. Translation: ACL32124.1.
RefSeqiWP_010786910.1. NC_011852.1.
YP_002475072.1. NC_011852.1.

Genome annotation databases

EnsemblBacteriaiACL32124; ACL32124; HAPS_0456.
GeneIDi7278461.
KEGGihap:HAPS_0456.
PATRICi20193183. VBIHaePar127548_0460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001321 Genomic DNA. Translation: ACL32124.1 .
RefSeqi WP_010786910.1. NC_011852.1.
YP_002475072.1. NC_011852.1.

3D structure databases

ProteinModelPortali B8F472.
ModBasei Search...

Protein-protein interaction databases

STRINGi 557723.HAPS_0456.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL32124 ; ACL32124 ; HAPS_0456 .
GeneIDi 7278461.
KEGGi hap:HAPS_0456.
PATRICi 20193183. VBIHaePar127548_0460.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci HPAR557723:GH24-456-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Haemophilus parasuis SH0165."
    Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R., Jin M., Jin Q., Chen H.
    J. Bacteriol. 191:1359-1360(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH0165.

Entry informationi

Entry nameiPYRF_HAEPS
AccessioniPrimary (citable) accession number: B8F472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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