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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Haemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateUniRule annotation1
Binding sitei32SubstrateUniRule annotation1
Active sitei61Proton donorUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei180SubstrateUniRule annotation1
Binding sitei189SubstrateUniRule annotation1
Binding sitei209Substrate; via amide nitrogenUniRule annotation1
Binding sitei210SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciHPAR557723:G1GUF-456-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:HAPS_0456
OrganismiHaemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeGlaesserella
Proteomesi
  • UP000006743 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001645721 – 230Orotidine 5'-phosphate decarboxylaseAdd BLAST230

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi557723.HAPS_0456

Structurei

3D structure databases

ProteinModelPortaliB8F472
SMRiB8F472
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 68Substrate bindingUniRule annotation10

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106EG9 Bacteria
COG0284 LUCA
HOGENOMiHOG000226071
KOiK01591
OMAiNFKIFLD

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_B OMPdecase_type1_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

B8F472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNKIIVALD YETEAEALNF VDQVDPSLCR LKVGKEMFTT LGTHFVKQLQ
60 70 80 90 100
DRKFDVFLDL KYHDIPNTVA RAVRSAADLG VWMVDLHACG GLRMMETAKQ
110 120 130 140 150
ILEPYGKDAP LLIGVTVLTS MEDLDLLQIG INASPMEQVI RLAHLCQRAG
160 170 180 190 200
LDGVVCSPQE VEVLRTHCGK DFKLVTPGIR PEGSDFGDQR RVMTPKQAIE
210 220 230
IGSDYLVIGR PITQAADPLA VLKSINQSIA
Length:230
Mass (Da):25,373
Last modified:March 3, 2009 - v1
Checksum:i5232E3CA4E4699DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA Translation: ACL32124.1
RefSeqiWP_010786910.1, NC_011852.1

Genome annotation databases

EnsemblBacteriaiACL32124; ACL32124; HAPS_0456
GeneIDi7278461
KEGGihap:HAPS_0456
PATRICifig|557723.8.peg.460

Similar proteinsi

Entry informationi

Entry nameiPYRF_HAEPS
AccessioniPrimary (citable) accession number: B8F472
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health