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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:HAPS_0018
OrganismiHaemophilus parasuis serovar 5 (strain SH0165)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000006743 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001924051 – 811Glycerol-3-phosphate acyltransferaseAdd BLAST811

Interactioni

Protein-protein interaction databases

STRINGi557723.HAPS_0018.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi303 – 308HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

B8F321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLLNLYRK ALNLPLSLLV KTRSIPTDPV NELGLKLDQP IVYVLPYTSQ
60 70 80 90 100
TDLLILQKNC QALNLPDPLV NNDIQGVSLS RFVFLDEGRR FFKSKGAKSE
110 120 130 140 150
TELVFYRYLD LNRNDEQLDI QVVPVSVLWG RAPGKEKGLP VLRLLGTFQR
160 170 180 190 200
LVTMLWFGRD NFIRFSQAVS LRYMITNHGT DENLAQKLAR VAKMHFAKQR
210 220 230 240 250
YSATGPQLPD RQAMFNKLLQ SPAILAAIED EAKKPKSSLE KARKEAEKIL
260 270 280 290 300
DEIAANVRHD SLRSADRVLS WLWNKLYQGI NVQYAERVRK LALEGHELVY
310 320 330 340 350
VPCHRSHMDY LLLSYILYHQ GLVPPHIAAG INLNFWPAGP IFRSWGAFFI
360 370 380 390 400
RRTFKGNRLY STIFREYLAE LFYRGYSVEY FIEGGRSRTG RLLDPKTGMM
410 420 430 440 450
SMTLQALQRG LTRPISIVPV YIGYEHVLEV DTYAKELRGA EKEKENAGLV
460 470 480 490 500
LRVIKKLKKL GQGYVNFGEP IPLNHYLNQY FPEWKEPLTD ENGRPKWLNS
510 520 530 540 550
AVEAVSKQVM VHINNAVAVN AKNLIGSVLL ASRQRSLTRE QLIEQVESYM
560 570 580 590 600
QLFKNVPYTA EVTLPTDTAE AMLDHVINLP RSGVISEKDN FGEIIRLDRQ
610 620 630 640 650
SAVLMTYYRN NIQHLFVLPS LVASIVLHHE TVSKDLIIQS VNRIYPFLQA
660 670 680 690 700
ELFMHFKAEE VRGHIEAILA EFVAQNLIKN ESDMFVINRQ RIRSLQLHSS
710 720 730 740 750
GVRELLQRYY ISLSILIEQP EISRNELEQE SRSIAQRLSV LHGINAPEFF
760 770 780 790 800
DKALFSTFSA TLKEQGYFDE EGDTIVSKVQ STEELIRGLI SVEIQHTVQG
810
AMVKLEEVNN I
Length:811
Mass (Da):92,931
Last modified:March 3, 2009 - v1
Checksum:i7BD590513281E20F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA. Translation: ACL31723.1.
RefSeqiWP_012621501.1. NC_011852.1.

Genome annotation databases

EnsemblBacteriaiACL31723; ACL31723; HAPS_0018.
GeneIDi7278633.
KEGGihap:HAPS_0018.
PATRICi20192298. VBIHaePar127548_0020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA. Translation: ACL31723.1.
RefSeqiWP_012621501.1. NC_011852.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi557723.HAPS_0018.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL31723; ACL31723; HAPS_0018.
GeneIDi7278633.
KEGGihap:HAPS_0018.
PATRICi20192298. VBIHaePar127548_0020.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_HAEPS
AccessioniPrimary (citable) accession number: B8F321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.