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B8ESV1 (ACDH_METSB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:Msil_1478
OrganismMethylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906) [Complete proteome] [HAMAP]
Taxonomic identifier395965 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBeijerinckiaceaeMethylocella

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387668

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding161 – 1699NAD By similarity

Sites

Active site1291Acyl-thioester intermediate By similarity
Binding site2881NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B8ESV1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: F584D180AB1C417D

FASTA31333,150
        10         20         30         40         50         60 
MEKIPCAIIG SGNIGTDLMI KIMRMSKHLE MGAMVGIDPK SDGLARAARL GVPVTHEGID 

        70         80         90        100        110        120 
GLRKLPNYGD IQIVFDATSA GAHVHNNAIL QKDGKKVIDL TPAAIGPFTI PAINGDANID 

       130        140        150        160        170        180 
EPNINMVTCG GQATIPMVRA VRRATDRVIW GEIVASISSK SAGPGTRANI DEFTETTSKA 

       190        200        210        220        230        240 
IEILGGAEHG KAIIILNPAE PPLIMRDTVF TLSQGGSRES IEQSILDMVA AVQKYVPGYR 

       250        260        270        280        290        300 
LKQKVQFENI GDNAPVRIPG VGLCSGLKTT IMLEVEGAAH YLPAYAGNLD IMTSAALVSA 

       310 
DHWAAKQLQK EAA 

« Hide

References

[1]"Complete genome sequence of the aerobic facultative methanotroph Methylocella silvestris BL2."
Chen Y., Crombie A., Rahman M.T., Dedysh S.N., Liesack W., Stott M.B., Alam M., Theisen A.R., Murrell J.C., Dunfield P.F.
J. Bacteriol. 192:3840-3841(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BL2 / DSM 15510 / NCIMB 13906.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001280 Genomic DNA. Translation: ACK50436.1.
RefSeqYP_002361798.1. NC_011666.1.

3D structure databases

ProteinModelPortalB8ESV1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING395965.Msil_1478.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK50436; ACK50436; Msil_1478.
GeneID7091821.
KEGGmsl:Msil_1478.
PATRIC22598465. VBIMetSil55537_1607.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAFTETTAH.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycMSIL395965:GCND-1506-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_METSB
AccessionPrimary (citable) accession number: B8ESV1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families