B8EPM3 (KHSE_METSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Msil_1259

Organism

Methylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906) [Complete proteome] [HAMAP]

Taxonomic identifier

395965 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Beijerinckiaceae › Methylocella

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_1000196946

Sequences

	Sequence		Length	Mass (Da)
	B8EPM3 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 0075FA3DCFC1FBF3	FASTA	321	34,728
	10 20 30 40 50 60 MAVYTEVSDA DLAAFLEHYN LGRVRALKGI AEGVENSNFV LSTETGVYIL TLYEKRVEEG 70 80 90 100 110 120 SLPFFLSLLD HLAARGLNCP QPVRMRSDGA LGRLAGRPAA IVTFLEGVCR NRPSIADCAR 130 140 150 160 170 180 LGAALAQLHL AAADFKGSRA NALNLEAWPK LFAPIAFRAD EVKAGLAATI SAELKFLQAN 190 200 210 220 230 240 WPRDLPRGII HADLFPDNVL FLGDEISGVI DFYFACVDDL SYDLAICLNA WCFEPGGAFN 250 260 270 280 290 300 IDKGAAMFGA YASLRPLSAA EAKAIPTLAR GAALRFALTR LVDWFNVPPG ALVNPKNPLE 310 320 YFAKLQMLQT IGDARELGVL I

References

[1]

"Complete sequence of Methylocella silvestris BL2." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Forester B., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Dunfield P.F., Dedysh S.N., Liesack W. , Stott M.B., Smirnova A.V., Alam M., Chen Y., Murrell J.C., Richardson P. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BL2 / DSM 15510 / NCIMB 13906.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001280 Genomic DNA. Translation: ACK50228.1.
RefSeq	YP_002361590.1. NC_011666.1.
3D structure databases
ProteinModelPortal	B8EPM3.
SMR	B8EPM3. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	B8EPM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7091268.
GenomeReviews	Gene locus Msil_1259 in contig CP001280_GR.
KEGG	msl:Msil_1259.
PATRIC	22598007. VBIMetSil55537_1382.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	CLSK2405699.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_METSB

Accession

Primary (citable) accession number: B8EPM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program