B8ELP6 (B8ELP6_METSB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	Msil_1071

Organism

Methylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906) [Complete proteome] [HAMAP] EMBL ACK50040.1

Taxonomic identifier

395965 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Beijerinckiaceae › Methylocella

Protein attributes

Sequence length	1145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004805
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS011708.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS011708 DNA replication HAMAP MF_01902 SAAS SAAS004805
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS011708
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004805 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8ELP6 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 79BB353D3F0A5A8B	FASTA	1,145	127,280
	10 20 30 40 50 60 MSPRYAELAA TTNFSFLRGA SHPEELVAAA MALGLAGLGI ADRNSLAGVV RAHRFLKANK 70 80 90 100 110 120 SPSFHLAIGA RLVFCDGAPD ILSYPRDRAA YGRLTRLLTR ANARAQKGVS LLRSSDLIEA 130 140 150 160 170 180 AQGQQLILMP ETTWEKGDET RRSRKIHAEL HDNNHYKNPV DLLDDAHALA FGQEMPLIEQ 190 200 210 220 230 240 LREASNGRLW LAAKMTYGVS MRRDLASRIA LSRKTNTPLI AVNDVIMHTP ERRPLQDVLS 250 260 270 280 290 300 AIRAGQTLDR LGLALEANAE RHMKSAAEMA RLFAGAPQAM EETLRFLDGL DFSLDELRGD 310 320 330 340 350 360 YPEELREGFE TPQAALAFFA REGAKFRFPD GVPPSVETAI AHELKLVEQL DYAPYFLTVH 370 380 390 400 410 420 DIVRFARTEK ILCQGRGSAA NSTLCYCLGV TEVNPAFHNL LFERFISPDR NEPPDIDVDF 430 440 450 460 470 480 EHERREQVMQ YIYARYGRAR AALTASVITY RARSAIREVG KAFGLSDDVV SALSATIWGG 490 500 510 520 530 540 SSSSVEAGEA QKAGFDPTEA RLAQTLKLAE ELIGFPRHLS QHTGGFVITR SRLDEVVPIM 550 560 570 580 590 600 NAAMEDRTTI EWDKDDLDAL GILKIDVLAL GMLTCLRKGF DLIREHYGEE LTIATLPPEQ 610 620 630 640 650 660 GAVYEMISRA DTIGVFQIES RAQMSMLPRL RPREFYDLVI EVAIVRPGPI QGDMVHPYLR 670 680 690 700 710 720 RRQGLEPVSY PSKQLEEVLG KTLGVPLFQE QAMKIAIVAA GFTPSEADQL RRAMATFKHV 730 740 750 760 770 780 GTIGAFRAKM IEGMVARDYS RDFAERCFKQ IEGFGSYGFP ESHAASFALL VYASAWMKCR 790 800 810 820 830 840 YPDAFACALL NAQPMGFYAP AQILRDAREH GVGVEEVDVN FSHWDSTLTP AAERRPPHPR 850 860 870 880 890 900 HASMQGEIFA TCGISLGFRQ IKGFAEHDAT QLVAMRDRGY DSIRDLWLRA GLSLAVMELL 910 920 930 940 950 960 AGADAFRSLG LDRREALWAV RGLNRAGDKD DLPLLKDLSW RATEAEAKLP PMLLGEHVVE 970 980 990 1000 1010 1020 DYRRLSLSLK AHPVSFLRER LTQKRILRAD DLKNQPAGSR ITVAGLVLVR QRPGTASGVI 1030 1040 1050 1060 1070 1080 FLTIEDETGI ANAIVWPKIF ERLRRIVIGA RFLAVTGRLQ KESDVIHVVM ERAEDLSPLL 1090 1100 1110 1120 1130 1140 ALLSDHGGAV SSLARADEVR RPNLRDSRAP REPVAPARSK PVETPSPAPP QEDWRRVLPK GRNFH

References

[1]

"Complete sequence of Methylocella silvestris BL2." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Forester B., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Dunfield P.F., Dedysh S.N., Liesack W. , Stott M.B., Smirnova A.V., Alam M., Chen Y., Murrell J.C., Richardson P. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BL2 / DSM 15510 / NCIMB 13906.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001280 Genomic DNA. Translation: ACK50040.1.
RefSeq	YP_002361402.1. NC_011666.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8ELP6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7091900.
GenomeReviews	Gene locus Msil_1071 in contig CP001280_GR.
KEGG	msl:Msil_1071.
PATRIC	22597607. VBIMetSil55537_1183.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734490.
OMA	EQPAIRL.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR012340. NA-bd_OB-fold. IPR004365. NA-bd_OB_tRNA-helicase. IPR004805. PolC_alpha. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8ELP6_METSB

Accession

Primary (citable) accession number: B8ELP6

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)