ID B8EKE2_METSB Unreviewed; 888 AA. AC B8EKE2; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 27-MAR-2024, entry version 74. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=Msil_1736 {ECO:0000313|EMBL:ACK50682.1}; OS Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB OS 13906 / BL2). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales; OC Beijerinckiaceae; Methylocella. OX NCBI_TaxID=395965 {ECO:0000313|EMBL:ACK50682.1, ECO:0000313|Proteomes:UP000002257}; RN [1] {ECO:0000313|EMBL:ACK50682.1, ECO:0000313|Proteomes:UP000002257} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2 RC {ECO:0000313|Proteomes:UP000002257}; RX PubMed=20472789; DOI=10.1128/JB.00506-10; RA Chen Y., Crombie A., Rahman M.T., Dedysh S.N., Liesack W., Stott M.B., RA Alam M., Theisen A.R., Murrell J.C., Dunfield P.F.; RT "Complete genome sequence of the aerobic facultative methanotroph RT Methylocella silvestris BL2."; RL J. Bacteriol. 192:3840-3841(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001280; ACK50682.1; -; Genomic_DNA. DR RefSeq; WP_012590752.1; NC_011666.1. DR AlphaFoldDB; B8EKE2; -. DR STRING; 395965.Msil_1736; -. DR KEGG; msl:Msil_1736; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_0_1_5; -. DR OrthoDB; 9802472at2; -. DR Proteomes; UP000002257; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR CDD; cd04862; PaeLigD_Pol_like; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR014143; NHEJ_ligase_prk. DR InterPro; IPR033651; PaeLigD_Pol-like. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACK50682.1}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Reference proteome {ECO:0000313|Proteomes:UP000002257}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 338..433 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 542..581 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 888 AA; 95708 MW; 41303A7E819AC29E CRC64; MADTKLKTYR AKRDFAQTAE PSGEAPIAAG PRRRFVIQKH AATRLHYDLR LELDGVFKSW AVTKGPSLDP HDKRLAVEVE DHPLDYGDFE GVIPKGQYGG GTVQLWDRGF WAPEGDKTPE QALADGDLKF TLDGQRLYGS WVLVRMKADR TGGKRTNWLL IKHRDGYARD GDADALLAED RSVASGRAMA AIAAGKGKGP KPFMLAGEQA ADPKAVWDSN KGLAAEARAA PKATRKKSGA ALAQMPDFLP PQLCQPVERP PSGDGWVHEI KFDGYRMQLR VAGGKATLKT RKGLDWTDKF AAIAAEAADF PDAIIDGEIV ALDSSGSPDF VALQAALSEQ NTDDLIFYAF DLMFEGGRDL RLEPLAARKQ ALARLIAGAR LGAGALIRFV EHFETGGDAI LQSACRLNLE GIVSKKRDAP YQPGRSDSWT RAKCRAGHEV VIGGWTTTEG KFRSLLAGVH HGENFTYIGR IGTGFGEAKV KTLLPKLKQF AAETSPFTGP SAPRKTASIH WLKPELVAEI EFAGFTGAGM VRQAAFKGLR EDKPAEEVEA ETPAPPEQAA VPDPAEIQAS ARSSSDKPMA TANGKPIVMG VAISNPAKEL WPADGAEAPV SKLDLARYYE AAGPWLIEHV RGRPCSLIRA PDGITGQQFF QRHAMAGASN LLDLVTVSGD RAPYLQIDRV EGLAAVAQIA GLELHPWNCA PGRPETPGRL IFDLDPGPDV AFEQVAAAAL EMRDRLDALG LVSFCKTTGG KGLHVVTPLA VAKGSKLTWP EAKGFAQEVC RRMAADNSNA YLLNMSKKLR AGRIFLDYLR NDRMSTAVAP LSPRARPGAT VSMPLNWSEA TNSLDPKAFT IRTSVGLLDK SKAWADYDSG ARPLEAAIKR LGRAKAAA //