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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Methylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei141 – 1411UniRule annotation
Active sitei578 – 5781UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMSIL395965:GCND-1747-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Msil_1718Imported
OrganismiMethylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906)Imported
Taxonomic identifieri395965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBeijerinckiaceaeMethylocella
ProteomesiUP000002257: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi395965.Msil_1718.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiDLRMTEQ.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8EKC5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELQAERRL EQALSVVDVS DGAPSGERIA AILYQLLLEV VQRHHPEIAP
60 70 80 90 100
VLSGETVLQN AAPEVLSRVF QAHGIWFQLL SIVEQDAAMG ERRRTERELG
110 120 130 140 150
EQAVPGTFAN VIAKAAKLGV PAADIAEKLG RTRVRPVITA HPTEAKRVTV
160 170 180 190 200
LEKHRRIYRL LVELEQPRWT GRERSGIIDQ LRDEIELLWM TGELRLEKPS
210 220 230 240 250
VEQEIAWGLH FFHETLFEGV PELLKKFDRA LKRFYPSENF ALTQFFQFGS
260 270 280 290 300
WIGGDRDGNP FVTNKVTRRA LRENAKASLR FYEQRLFNLM KSLSISERAL
310 320 330 340 350
PPPSGFREAL NRALSDSGDG AGIALRNPGE PYRQFLYCAH AKVKATLALY
360 370 380 390 400
EGERTPGPHY ISADDLISDL AVTEQALAES GSVGLAQDLV RPVRFAVEAF
410 420 430 440 450
RFRTQRLDLR ENTTKLTSTL QALWRAMHTE ADGEPPAVES DEWKAWILAE
460 470 480 490 500
LARPRIGPPV YRALPPEAEE TLGMFKLARD RDEEFDREAF GSFVLSMTRS
510 520 530 540 550
AADVLGAYLL AKEADLYHDA TRVEACTLSI TPLFETITDL RAAPQIMREL
560 570 580 590 600
LSLPLVRRSA RMQGGVQEVM IGYSDSNKDG GFLSSNWELA KAQDKLAKIG
610 620 630 640 650
AEAGIPISFF HGRGGSVSRG GAPTAQAIAA QPAGSIQGRL RVTEQGEVVS
660 670 680 690 700
FKYANRGTAA FQMEMLGSSV FEHTLTLERA APALRAEFEE AMEALSGASH
710 720 730 740 750
AAYANFINHP DLLTYFQSAS PLDEISMLNI GSRPARRFGA RTLSDLRAIP
760 770 780 790 800
WVFAWAQNRH VITGWYGVGS GIASFLDVRK ERGLTLLKRM FAESDLFRMI
810 820 830 840 850
VGEVEKTLGM VDLDIAREYA GLVYDDDVRE TIFGMIEAEY RLTRANILKI
860 870 880 890 900
TGEEEIAQRF PAYRSRLETR LKTINKVNRE QVELLRNFRA STNELSKEAF
910
KSNLLLSINC ISSGLGATG
Length:919
Mass (Da):102,507
Last modified:March 3, 2009 - v1
Checksum:iDB7EC507D4F1DB02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001280 Genomic DNA. Translation: ACK50665.1.
RefSeqiWP_012590735.1. NC_011666.1.
YP_002362027.1. NC_011666.1.

Genome annotation databases

EnsemblBacteriaiACK50665; ACK50665; Msil_1718.
GeneIDi7093178.
KEGGimsl:Msil_1718.
PATRICi22598975. VBIMetSil55537_1861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001280 Genomic DNA. Translation: ACK50665.1.
RefSeqiWP_012590735.1. NC_011666.1.
YP_002362027.1. NC_011666.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395965.Msil_1718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK50665; ACK50665; Msil_1718.
GeneIDi7093178.
KEGGimsl:Msil_1718.
PATRICi22598975. VBIMetSil55537_1861.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiDLRMTEQ.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciMSIL395965:GCND-1747-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the aerobic facultative methanotroph Methylocella silvestris BL2."
    Chen Y., Crombie A., Rahman M.T., Dedysh S.N., Liesack W., Stott M.B., Alam M., Theisen A.R., Murrell J.C., Dunfield P.F.
    J. Bacteriol. 192:3840-3841(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BL2 / DSM 15510 / NCIMB 13906Imported.

Entry informationi

Entry nameiB8EKC5_METSB
AccessioniPrimary (citable) accession number: B8EKC5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.