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B8EKB9

- FTHS_METSB

UniProt

B8EKB9 - FTHS_METSB

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSIL395965:GCND-1741-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Msil_1712
    OrganismiMethylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906)
    Taxonomic identifieri395965 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBeijerinckiaceaeMethylocella
    ProteomesiUP000002257: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_1000185259Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi395965.Msil_1712.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8EKB9-1 [UniParc]FASTAAdd to Basket

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    MASDIEIAQR ATMERITKVA AEKLGIDDEH LEPYGHFKAK ISLDYVDSLK    50
    DRPDGKLILV TAISPTPAGE GKTTTTVGLG DALNRIGKKA SICLREPSLG 100
    PVFGMKGGAA GGGYAQVVPM EDINLHFTGD FSAIALATNL LAAMIDNHIH 150
    HGNELNIDVR RIAWKRVVDM NDRALRDITI ALGGTANGFP RQDGFDIVVA 200
    SEVMAIFCLA NSIEDLKARL GAIVIGYTTD QKPVHARDLQ ANGAMAVLLK 250
    NALKPNLVQT LENNPAFIHG GPFANIAHGC NSVLATKTAL KLSDYVVTEA 300
    GFGADLGAEK FIDIKCRKSG LRPQAVVIVA TIRALKYHGG VELKELNTEN 350
    LDALRKGLSN LERHINNIRN HYGLPVVVAI NHFTADTAAE VDLLKKSVAD 400
    LGAPIVVCRH WAEGGKGAED LARVVVEMID KVPSDFHFVY EDSASLWDKA 450
    TAVATKLYGA TKVTADAKVR NQIKKLEESG YGNFPICIAK TQYSFSTDAK 500
    LRGAPTGHDI NIREVRLAAG AEFIVLVCGD VMTMPGLPKI PSATKIDLNE 550
    KGEVVGLF 558
    Length:558
    Mass (Da):59,937
    Last modified:March 3, 2009 - v1
    Checksum:iB46A8350F0EE0257
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001280 Genomic DNA. Translation: ACK50659.1.
    RefSeqiWP_012590729.1. NC_011666.1.
    YP_002362021.1. NC_011666.1.

    Genome annotation databases

    EnsemblBacteriaiACK50659; ACK50659; Msil_1712.
    GeneIDi7093172.
    KEGGimsl:Msil_1712.
    PATRICi22598959. VBIMetSil55537_1853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001280 Genomic DNA. Translation: ACK50659.1 .
    RefSeqi WP_012590729.1. NC_011666.1.
    YP_002362021.1. NC_011666.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395965.Msil_1712.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK50659 ; ACK50659 ; Msil_1712 .
    GeneIDi 7093172.
    KEGGi msl:Msil_1712.
    PATRICi 22598959. VBIMetSil55537_1853.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MSIL395965:GCND-1741-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the aerobic facultative methanotroph Methylocella silvestris BL2."
      Chen Y., Crombie A., Rahman M.T., Dedysh S.N., Liesack W., Stott M.B., Alam M., Theisen A.R., Murrell J.C., Dunfield P.F.
      J. Bacteriol. 192:3840-3841(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BL2 / DSM 15510 / NCIMB 13906.

    Entry informationi

    Entry nameiFTHS_METSB
    AccessioniPrimary (citable) accession number: B8EKB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3