B8EJZ2 (AHPD_METSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	Msil_0970

Organism

Methylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906) [Complete proteome] [HAMAP]

Taxonomic identifier

395965 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Beijerinckiaceae › Methylocella

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_1000187336
Sites
	Active site	131	1	Proton donor By similarity
	Active site	134	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	131 ↔ 134		Alternate By similarity
	Disulfide bond	134		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8EJZ2 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: CEC418A92D42F592	FASTA	178	18,854
	10 20 30 40 50 60 MSIDSLKGQL PDFAKDVRLN LGSIANDDSL KEQTKYGLLL ACALASRNAE VAAAFDREAA 70 80 90 100 110 120 SHLTPEARDA ARAAATIMGM NNVYYRFVHL ASNPVYKTMP AKLRMGVIGS PGVPKTDFEL 130 140 150 160 170 WCLAVSAING CGMCIDAHEK VLADAGVTQE VIQTAVRFAA IVQSAAIALE AAQLPAFA

References

[1]

"Complete sequence of Methylocella silvestris BL2." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Forester B., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Dunfield P.F., Dedysh S.N., Liesack W. , Stott M.B., Smirnova A.V., Alam M., Chen Y., Murrell J.C., Richardson P. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BL2 / DSM 15510 / NCIMB 13906.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001280 Genomic DNA. Translation: ACK49939.1.
RefSeq	YP_002361301.1. NC_011666.1.
3D structure databases
ProteinModelPortal	B8EJZ2.
ModBase	Search...
Protein-protein interaction databases
STRING	B8EJZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7093649.
GenomeReviews	Gene locus Msil_0970 in contig CP001280_GR.
KEGG	msl:Msil_0970.
PATRIC	22597369. VBIMetSil55537_1065.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG414634.
OMA	RAGLRMN.
ProtClustDB	CLSK2405726.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_METSB

Accession

Primary (citable) accession number: B8EJZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program