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B8EJ84 (HEMH_METSB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Msil_3692
OrganismMethylocella silvestris (strain BL2 / DSM 15510 / NCIMB 13906) [Complete proteome] [HAMAP]
Taxonomic identifier395965 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Beijerinckiaceae › Methylocella

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Ferrochelatase HAMAP MF_00323
PRO_1000189987

Sites

Metal binding2181Iron By similarity
Metal binding2991Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B8EJ84 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: BFE4F6A07563C584

FASTA34839,218
        10         20         30         40         50         60 
MTAETAAVDA RPVASSQRVG VLLVNLGTPD ALGYWPVRRY LKEFLSDRRV VNTPRLIWWP 

        70         80         90        100        110        120 
ILNLIILTTR PQRSSKNYET IWNSQRNESP LKTVTRSQAE QLAGSIVSGE FGAGGDIVVD 

       130        140        150        160        170        180 
WAMRYANPSI LSSLQRLREQ GCGRVLIVPL YPQFAGATTL SVADKVEESL ARMNWRPDMR 

       190        200        210        220        230        240 
SVPPYYNDPV YIDALAQSVR AGLAALDFEP EVVLVSFHGI PKSYVEAGDP YYDQCVETWR 

       250        260        270        280        290        300 
LLRERLDFSP ERCPLTFQSR FGRAEWLSPY TDETVKELAR KGVRRMAVLT PGFSVDCLET 

       310        320        330        340 
ISEIGVENRE FFIEAGGEQF ALIPCLNDSA LGMKVIRHIV SRELEGWI

« Hide

References

[1]"Complete sequence of Methylocella silvestris BL2."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Forester B., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Dunfield P.F., Dedysh S.N., Liesack W. expand/collapse author list , Stott M.B., Smirnova A.V., Alam M., Chen Y., Murrell J.C., Richardson P.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BL2 / DSM 15510 / NCIMB 13906.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001280 Genomic DNA. Translation: ACK52576.1.
RefSeqYP_002363938.1. NC_011666.1.

3D structure databases

ProteinModelPortalB8EJ84.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8EJ84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7093046.
GenomeReviewsGene locus Msil_3692 in contig CP001280_GR.
KEGGmsl:Msil_3692.
PATRIC22603216. VBIMetSil55537_3955.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_METSB
AccessionPrimary (citable) accession number: B8EJ84
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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