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Protein

Cytidine deaminase

Gene

cdd

Organism
Shewanella baltica (strain OS223)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Zinc; catalyticUniRule annotation1
Active sitei103Proton donorUniRule annotation1
Metal bindingi128Zinc; catalyticUniRule annotation1
Metal bindingi131Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminaseUniRule annotation (EC:3.5.4.5UniRule annotation)
Alternative name(s):
Cytidine aminohydrolaseUniRule annotation
Short name:
CDAUniRule annotation
Gene namesi
Name:cddUniRule annotation
Ordered Locus Names:Sbal223_2663
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001854181 – 296Cytidine deaminaseAdd BLAST296

Proteomic databases

PRIDEiB8EF35

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8EF35
SMRiB8EF35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 167CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd BLAST121
Domaini186 – 296CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 90Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218617
KOiK01489
OMAiGHIDAQQ

Family and domain databases

HAMAPiMF_01558 Cyt_deam, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR013171 Cyd/dCyd_deaminase_Zn-bd
IPR016193 Cytidine_deaminase-like
IPR020797 Cytidine_deaminase_bacteria
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
PF08211 dCMP_cyt_deam_2, 1 hit
SUPFAMiSSF53927 SSF53927, 2 hits
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 2 hits

Sequencei

Sequence statusi: Complete.

B8EF35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDRFIRSIT QLPTPLADAL IPMLHQNFAG HLDAQQLATL TSASKMTEAE
60 70 80 90 100
VLLALLPIAA ALAKPPISEF YVGAIAKGKS GDIYMGANLE LPGEALFHSV
110 120 130 140 150
HAEQSAISHA WLSGESQIVD IIVNASPCGH CRQFMNELVE GSKISIHLPA
160 170 180 190 200
QESHPLAYYL PYAFGPKDLN VTSPLMAKQQ TEFALDSADP MIIEGLDHAG
210 220 230 240 250
LSYAPYTQSF AAVVLETRDG ATYCGRYAEN AAFNPSMLPM QMALSNLVRH
260 270 280 290
NREFSDISRA VLIESSQGKI SLVGATMDAL HTVAAIELEH IVIDPV
Length:296
Mass (Da):31,951
Last modified:March 3, 2009 - v1
Checksum:i38576F5FF2B0442E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA Translation: ACK47153.1
RefSeqiWP_006087443.1, NC_011663.1

Genome annotation databases

EnsemblBacteriaiACK47153; ACK47153; Sbal223_2663
GeneIDi11771940
KEGGisbp:Sbal223_2663

Entry informationi

Entry nameiCDD_SHEB2
AccessioniPrimary (citable) accession number: B8EF35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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