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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella baltica (strain OS223)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAL407976:GJ6Y-3863-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sbal223_3748
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002507 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Formate--tetrahydrofolate ligasePRO_1000185262Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB8ECE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGNSKSGE.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ECE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTDMDISSR ASLKNITELG ADLGLLPEEM MLFGHTKAKV ELSVLQRLAG
60 70 80 90 100
QRKGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLNAIGQKAC ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYAQVVPMQ EMNLHLTGDI HAVSSAHNLG AAAIAARLFH
160 170 180 190 200
EARLGKTEFE AQSGQAFLDI APNEIRWHRV VDHNDRCLRQ IHVGLGDNNG
210 220 230 240 250
PEYGSSFDIT AASELMAILA LSHDLADMRA RIGRLVLALN TQGQVITAED
260 270 280 290 300
LGVAGAMTAI MADAIKPTLM QTLNGSPCLI HSGPFANIAH GNSSIIADDI
310 320 330 340 350
ALRLADFVVT EGGFGSDMGF EKFCNIKVRQ SGQAPAAAVL VTTLKALKAN
360 370 380 390 400
SGLATEVDSN APNIHVPNIN APDQARLEAG FANLNWHINN VARYGIPVVV
410 420 430 440 450
GINRFATDSD AELQWLMEAV NASAAFGCEI SDAFSQGEAG AIALARTVVR
460 470 480 490 500
AAETESQFKL LYPDEASLEA KLSTLAEVGY GASGVSLSIE AKQQAQQLTA
510 520 530 540 550
LGYGHLPLCM AKTPLSISHD PSLKGVPKDF VVPVRELVLH AGAGFITALV
560 570 580
GNVMTMPGLG LKPGYLKIDI DAKGEIVGLG
Length:580
Mass (Da):60,863
Last modified:March 3, 2009 - v1
Checksum:i7A60C1B3357091C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA. Translation: ACK48226.1.
RefSeqiWP_012588639.1. NC_011663.1.
YP_002359649.1. NC_011663.1.

Genome annotation databases

EnsemblBacteriaiACK48226; ACK48226; Sbal223_3748.
KEGGisbp:Sbal223_3748.
PATRICi23483918. VBISheBal125792_3876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA. Translation: ACK48226.1.
RefSeqiWP_012588639.1. NC_011663.1.
YP_002359649.1. NC_011663.1.

3D structure databases

ProteinModelPortaliB8ECE1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK48226; ACK48226; Sbal223_3748.
KEGGisbp:Sbal223_3748.
PATRICi23483918. VBISheBal125792_3876.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGNSKSGE.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciSBAL407976:GJ6Y-3863-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS223.

Entry informationi

Entry nameiFTHS_SHEB2
AccessioniPrimary (citable) accession number: B8ECE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: June 24, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.