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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella baltica (strain OS223)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAL407976:G1GU6-3908-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sbal223_3748
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002507 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001852621 – 580Formate--tetrahydrofolate ligaseAdd BLAST580

Proteomic databases

PRIDEiB8ECE1

Structurei

3D structure databases

ProteinModelPortaliB8ECE1
SMRiB8ECE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit

Sequencei

Sequence statusi: Complete.

B8ECE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTDMDISSR ASLKNITELG ADLGLLPEEM MLFGHTKAKV ELSVLQRLAG
60 70 80 90 100
QRKGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLNAIGQKAC ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYAQVVPMQ EMNLHLTGDI HAVSSAHNLG AAAIAARLFH
160 170 180 190 200
EARLGKTEFE AQSGQAFLDI APNEIRWHRV VDHNDRCLRQ IHVGLGDNNG
210 220 230 240 250
PEYGSSFDIT AASELMAILA LSHDLADMRA RIGRLVLALN TQGQVITAED
260 270 280 290 300
LGVAGAMTAI MADAIKPTLM QTLNGSPCLI HSGPFANIAH GNSSIIADDI
310 320 330 340 350
ALRLADFVVT EGGFGSDMGF EKFCNIKVRQ SGQAPAAAVL VTTLKALKAN
360 370 380 390 400
SGLATEVDSN APNIHVPNIN APDQARLEAG FANLNWHINN VARYGIPVVV
410 420 430 440 450
GINRFATDSD AELQWLMEAV NASAAFGCEI SDAFSQGEAG AIALARTVVR
460 470 480 490 500
AAETESQFKL LYPDEASLEA KLSTLAEVGY GASGVSLSIE AKQQAQQLTA
510 520 530 540 550
LGYGHLPLCM AKTPLSISHD PSLKGVPKDF VVPVRELVLH AGAGFITALV
560 570 580
GNVMTMPGLG LKPGYLKIDI DAKGEIVGLG
Length:580
Mass (Da):60,863
Last modified:March 3, 2009 - v1
Checksum:i7A60C1B3357091C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA Translation: ACK48226.1
RefSeqiWP_012588639.1, NC_011663.1

Genome annotation databases

EnsemblBacteriaiACK48226; ACK48226; Sbal223_3748
KEGGisbp:Sbal223_3748

Similar proteinsi

Entry informationi

Entry nameiFTHS_SHEB2
AccessioniPrimary (citable) accession number: B8ECE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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