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B8ECE1

- FTHS_SHEB2

UniProt

B8ECE1 - FTHS_SHEB2

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella baltica (strain OS223)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAL407976:GJ6Y-3863-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sbal223_3748
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002507: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Formate--tetrahydrofolate ligasePRO_1000185262Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi407976.Sbal223_3748.

Structurei

3D structure databases

ProteinModelPortaliB8ECE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiKWNISYT.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ECE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTDMDISSR ASLKNITELG ADLGLLPEEM MLFGHTKAKV ELSVLQRLAG
60 70 80 90 100
QRKGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLNAIGQKAC ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYAQVVPMQ EMNLHLTGDI HAVSSAHNLG AAAIAARLFH
160 170 180 190 200
EARLGKTEFE AQSGQAFLDI APNEIRWHRV VDHNDRCLRQ IHVGLGDNNG
210 220 230 240 250
PEYGSSFDIT AASELMAILA LSHDLADMRA RIGRLVLALN TQGQVITAED
260 270 280 290 300
LGVAGAMTAI MADAIKPTLM QTLNGSPCLI HSGPFANIAH GNSSIIADDI
310 320 330 340 350
ALRLADFVVT EGGFGSDMGF EKFCNIKVRQ SGQAPAAAVL VTTLKALKAN
360 370 380 390 400
SGLATEVDSN APNIHVPNIN APDQARLEAG FANLNWHINN VARYGIPVVV
410 420 430 440 450
GINRFATDSD AELQWLMEAV NASAAFGCEI SDAFSQGEAG AIALARTVVR
460 470 480 490 500
AAETESQFKL LYPDEASLEA KLSTLAEVGY GASGVSLSIE AKQQAQQLTA
510 520 530 540 550
LGYGHLPLCM AKTPLSISHD PSLKGVPKDF VVPVRELVLH AGAGFITALV
560 570 580
GNVMTMPGLG LKPGYLKIDI DAKGEIVGLG
Length:580
Mass (Da):60,863
Last modified:March 3, 2009 - v1
Checksum:i7A60C1B3357091C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA. Translation: ACK48226.1.
RefSeqiWP_012588639.1. NC_011663.1.
YP_002359649.1. NC_011663.1.

Genome annotation databases

EnsemblBacteriaiACK48226; ACK48226; Sbal223_3748.
GeneIDi7087412.
KEGGisbp:Sbal223_3748.
PATRICi23483918. VBISheBal125792_3876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA. Translation: ACK48226.1 .
RefSeqi WP_012588639.1. NC_011663.1.
YP_002359649.1. NC_011663.1.

3D structure databases

ProteinModelPortali B8ECE1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 407976.Sbal223_3748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK48226 ; ACK48226 ; Sbal223_3748 .
GeneIDi 7087412.
KEGGi sbp:Sbal223_3748.
PATRICi 23483918. VBISheBal125792_3876.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi KWNISYT.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SBAL407976:GJ6Y-3863-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS223.

Entry informationi

Entry nameiFTHS_SHEB2
AccessioniPrimary (citable) accession number: B8ECE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3