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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Shewanella baltica (strain OS223)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Sbal223_1871)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAL407976:G1GU6-582-MONOMER
UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:Sbal223_0555
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002507 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001229291 – 367Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST367

Structurei

3D structure databases

ProteinModelPortaliB8E8I2
SMRiB8E8I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230361
KOiK01923
OMAiQKARPVM

Family and domain databases

HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR014106 SAICAR_synthase_Vibrio-typ
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
TIGRFAMsiTIGR02735 purC_vibrio, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

B8E8I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLADSVLAI NNDLPIRTDS PVHSGKVRSV YWLTDADSRR LITTKGYNVP
60 70 80 90 100
EDTPLAIMVI SDRISAFDCI FHGEGGLKGI PGKGAALNAI SNHWFKLFAE
110 120 130 140 150
NGLADSHILD IPHPFVWIVQ KARPIKVEAI CRQYITGSMW RAYSKGERVF
160 170 180 190 200
CGITLPEGLE KDQKLPELLI TPSTKGILTG IPGVPAQDDV NISRSDIEAN
210 220 230 240 250
YQAFGFEKLA DIDLYEKLLK DGFKVISKAL ADIDQVFVDT KFEFGYVTDK
260 270 280 290 300
DGNSKLIYMD EVGTPDSSRI WDGAAYRDGK ILENSKEGFR QFLLNHFPDP
310 320 330 340 350
DVLLNKDRMP EREALARDND LPLEAMMQVS RTYTGVAEKV TGAPIPLPAN
360
PKADIIKILK DEYDLIV
Length:367
Mass (Da):40,814
Last modified:March 3, 2009 - v1
Checksum:i5959399D96E8AB22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA Translation: ACK45089.1
RefSeqiWP_012586692.1, NC_011663.1

Genome annotation databases

EnsemblBacteriaiACK45089; ACK45089; Sbal223_0555
KEGGisbp:Sbal223_0555

Similar proteinsi

Entry informationi

Entry nameiPUR7_SHEB2
AccessioniPrimary (citable) accession number: B8E8I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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