B8E8I2 (PUR7_SHEB2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	Sbal223_0555

Organism

Shewanella baltica (strain OS223) [Complete proteome] [HAMAP]

Taxonomic identifier

407976 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000122929

Sequences

	Sequence		Length	Mass (Da)
	B8E8I2 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 5959399D96E8AB22	FASTA	367	40,814
	10 20 30 40 50 60 MSLADSVLAI NNDLPIRTDS PVHSGKVRSV YWLTDADSRR LITTKGYNVP EDTPLAIMVI 70 80 90 100 110 120 SDRISAFDCI FHGEGGLKGI PGKGAALNAI SNHWFKLFAE NGLADSHILD IPHPFVWIVQ 130 140 150 160 170 180 KARPIKVEAI CRQYITGSMW RAYSKGERVF CGITLPEGLE KDQKLPELLI TPSTKGILTG 190 200 210 220 230 240 IPGVPAQDDV NISRSDIEAN YQAFGFEKLA DIDLYEKLLK DGFKVISKAL ADIDQVFVDT 250 260 270 280 290 300 KFEFGYVTDK DGNSKLIYMD EVGTPDSSRI WDGAAYRDGK ILENSKEGFR QFLLNHFPDP 310 320 330 340 350 360 DVLLNKDRMP EREALARDND LPLEAMMQVS RTYTGVAEKV TGAPIPLPAN PKADIIKILK DEYDLIV

References

[1]

"Complete sequence of chromosome of Shewanella baltica OS223." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L. , Kyrpides N., Ovchinnikova G., Brettar I., Rodrigues J., Konstantinidis K., Tiedje J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS223.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001252 Genomic DNA. Translation: ACK45089.1.
RefSeq	YP_002356512.1. NC_011663.1.
3D structure databases
ProteinModelPortal	B8E8I2.
ModBase	Search...
Protein-protein interaction databases
STRING	B8E8I2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7089286.
GenomeReviews	Gene locus Sbal223_0555 in contig CP001252_GR.
KEGG	sbp:Sbal223_0555.
PATRIC	23477096. VBISheBal125792_0568.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG555040.
OMA	SSRIWDG.
ProtClustDB	PRK13960.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02735. PurC_vibrio. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_SHEB2

Accession

Primary (citable) accession number: B8E8I2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program