B8E7Q4 (B8E7Q4_SHEB2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387
Short name=UDP-N-acetylglucosamine acyltransferase HAMAP MF_00387
EC=2.3.1.129 HAMAP MF_00387

Gene names

Name:	lpxA HAMAP MF_00387
Ordered Locus Names:	Sbal223_2890

Organism

Shewanella baltica (strain OS223) [Complete proteome] [HAMAP]

Taxonomic identifier

407976 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387
Subunit structure	Homotrimer By similarity. HAMAP MF_00387
Subcellular location	Cytoplasm By similarity HAMAP MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily. HAMAP MF_00387

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00387 Lipid synthesis
Cellular component	Cytoplasm HAMAP MF_00387
Domain	Repeat HAMAP MF_00387
Molecular function	Acyltransferase HAMAP MF_00387 EMBL ACK47376.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8E7Q4 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: ADA74AAE8DFFD376	FASTA	256	27,842
	10 20 30 40 50 60 MIDTLAFVHP DAKIGNNVTI GPWTYIGAGV EIGDDCWLSS HVVVKGPTII GKGNRIFQFA 70 80 90 100 110 120 SVGEECQDKK YAGEPTRLII GDNNVIRENV TIHRGTVQDN SETRIGSNNL FMNYVHIAHD 130 140 150 160 170 180 CVVGDNVIMA NNASIAGHVH VGDWAILGGM TGVHQFVHIG AHAFTAGCSL VLQDVPPFVM 190 200 210 220 230 240 AAGQPTIPRG LNSEGMKRRG FSKESQLAVR RAYKTLYRSS LTVEEAIEAL AEDAQNDEQV 250 KLFLEFVKSS SRGIIR

References

[1]

"Complete sequence of chromosome of Shewanella baltica OS223." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L. , Kyrpides N., Ovchinnikova G., Brettar I., Rodrigues J., Konstantinidis K., Tiedje J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS223.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001252 Genomic DNA. Translation: ACK47376.1.
RefSeq	YP_002358799.1. NC_011663.1.
3D structure databases
ProteinModelPortal	B8E7Q4.
SMR	B8E7Q4. Positions 2-256.
ModBase	Search...
Protein-protein interaction databases
STRING	B8E7Q4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7089459.
GenomeReviews	Gene locus Sbal223_2890 in contig CP001252_GR.
KEGG	sbp:Sbal223_2890.
PATRIC	23482107. VBISheBal125792_2982.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG659295.
OMA	REFCTFN.
ProtClustDB	PRK05289.
Family and domain databases
HAMAP	MF_00387. LpxA. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00677.
Pfam	PF00132. Hexapep. 4 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. Lipid_A_lpxA. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8E7Q4_SHEB2

Accession

Primary (citable) accession number: B8E7Q4

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)