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B8E7Q3

- LPXB_SHEB2

UniProt

B8E7Q3 - LPXB_SHEB2

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Sbal223_2889
Organism
Shewanella baltica (strain OS223)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSBAL407976:GJ6Y-2991-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Sbal223_2889
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002507: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000191490Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi407976.Sbal223_2889.

Structurei

3D structure databases

ProteinModelPortaliB8E7Q3.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B8E7Q3-1 [UniParc]FASTAAdd to Basket

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MSNKTPLVFA MVAGELSGDI LGAGLMAALQ KNHPDARFVG IGGPRMEALG    50
FRSLFAMEEL AVMGIVEVLS RLPRLLTVRA SLIKEITALK PDCFIGIDAP 100
DFNIGLELKL KARGIKTVHY VSPSVWAWRP KRIFKIAKAT HMVLSLLPFE 150
KAFYDQHQVP CTFVGHTLAD DIPFQSDKAA ARALLGLDAD AEYLAILPGS 200
RGGELKQLAE PFVKAALLIR QNFPDIRFVT PLVNQKRRDQ FEQALKDFAP 250
DLEIHMIEGQ SREVMAAADG ILLASGTATL EAMLVKRPMV VAYRVSPITY 300
RIAKRMMQVE RFSLPNLLAG KDLVPELIQE DCTPEKIAAA VTLELNRDFA 350
PLKAEFEALH QVLRRDASLK AAEAVMALVE PKHTQAKSPE AN 392
Length:392
Mass (Da):43,181
Last modified:March 3, 2009 - v1
Checksum:i39BFC1B49628906B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001252 Genomic DNA. Translation: ACK47375.1.
RefSeqiWP_012588123.1. NC_011663.1.
YP_002358798.1. NC_011663.1.

Genome annotation databases

EnsemblBacteriaiACK47375; ACK47375; Sbal223_2889.
GeneIDi7089458.
KEGGisbp:Sbal223_2889.
PATRICi23482105. VBISheBal125792_2981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001252 Genomic DNA. Translation: ACK47375.1 .
RefSeqi WP_012588123.1. NC_011663.1.
YP_002358798.1. NC_011663.1.

3D structure databases

ProteinModelPortali B8E7Q3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 407976.Sbal223_2889.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK47375 ; ACK47375 ; Sbal223_2889 .
GeneIDi 7089458.
KEGGi sbp:Sbal223_2889.
PATRICi 23482105. VBISheBal125792_2981.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SBAL407976:GJ6Y-2991-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS223.

Entry informationi

Entry nameiLPXB_SHEB2
AccessioniPrimary (citable) accession number: B8E7Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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