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B8E7Q3 (LPXB_SHEB2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:Sbal223_2889
OrganismShewanella baltica (strain OS223) [Complete proteome] [HAMAP]
Taxonomic identifier407976 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_1000191490

Sequences

Sequence LengthMass (Da)Tools
B8E7Q3 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 39BFC1B49628906B

FASTA39243,181
        10         20         30         40         50         60 
MSNKTPLVFA MVAGELSGDI LGAGLMAALQ KNHPDARFVG IGGPRMEALG FRSLFAMEEL 

        70         80         90        100        110        120 
AVMGIVEVLS RLPRLLTVRA SLIKEITALK PDCFIGIDAP DFNIGLELKL KARGIKTVHY 

       130        140        150        160        170        180 
VSPSVWAWRP KRIFKIAKAT HMVLSLLPFE KAFYDQHQVP CTFVGHTLAD DIPFQSDKAA 

       190        200        210        220        230        240 
ARALLGLDAD AEYLAILPGS RGGELKQLAE PFVKAALLIR QNFPDIRFVT PLVNQKRRDQ 

       250        260        270        280        290        300 
FEQALKDFAP DLEIHMIEGQ SREVMAAADG ILLASGTATL EAMLVKRPMV VAYRVSPITY 

       310        320        330        340        350        360 
RIAKRMMQVE RFSLPNLLAG KDLVPELIQE DCTPEKIAAA VTLELNRDFA PLKAEFEALH 

       370        380        390 
QVLRRDASLK AAEAVMALVE PKHTQAKSPE AN 

« Hide

References

[1]"Complete sequence of chromosome of Shewanella baltica OS223."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Ovchinnikova G., Brettar I., Rodrigues J., Konstantinidis K., Tiedje J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OS223.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001252 Genomic DNA. Translation: ACK47375.1.
RefSeqYP_002358798.1. NC_011663.1.

3D structure databases

ProteinModelPortalB8E7Q3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING407976.Sbal223_2889.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK47375; ACK47375; Sbal223_2889.
GeneID7089458.
KEGGsbp:Sbal223_2889.
PATRIC23482105. VBISheBal125792_2981.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.
ProtClustDBPRK00025.

Enzyme and pathway databases

BioCycSBAL407976:GJ6Y-2991-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_SHEB2
AccessionPrimary (citable) accession number: B8E7Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways