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B8E6P5

- TYPH_SHEB2

UniProt

B8E6P5 - TYPH_SHEB2

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Protein
Thymidine phosphorylase
Gene
deoA, Sbal223_1141
Organism
Shewanella baltica (strain OS223)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSBAL407976:GJ6Y-1173-MONOMER.
UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:deoA
Ordered Locus Names:Sbal223_1141
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002507: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Thymidine phosphorylaseUniRule annotation
PRO_1000186273Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi407976.Sbal223_1141.

Structurei

3D structure databases

ProteinModelPortaliB8E6P5.
SMRiB8E6P5. Positions 1-438.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000047313.
KOiK00758.
OMAiFINGVRD.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_01628. Thymid_phosp.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8E6P5-1 [UniParc]FASTAAdd to Basket

« Hide

MFLAQEIIRK KRNGLALSSE EIQFFVQGIT TNSVSEGQIA ALGMAVYFND    50
MNMDERIALT TAMRDSGTVL NWQSLGLNGP VIDKHSTGGV GDVISLMLGP 100
MAAACGGYVP MISGRGLGHT GGTLDKFDAI PGYQTEPSSE LFRKVVKDVG 150
VAIIGQTGDL VPADKRFYSI RDNTATVESI SLITASILSK KLACNLDALA 200
MDVKVGSGAF MPTYEASEEL ARSIAAVANG AGTKTTALLT DMNQVLASCA 250
GNAVEVKEAI DFLTGAYRNP RLYEVTMGLC AEMLLLGGLA SNEADARAKL 300
NRVLDNGRAA ELFGKMVSGL GGPVDFVENY SKYLPQSQII RPVFADMQGY 350
AYSMDTRELG LAVVTLGGGR RKPGDALDYS VGLTQVCALG DKVDSSTPIA 400
VIHAQSEAAF AEAELAVKKA IHIGETAPEK TPEIYAYIRA SDL 443
Length:443
Mass (Da):46,876
Last modified:March 3, 2009 - v1
Checksum:iCF95BCFAE77BE4CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001252 Genomic DNA. Translation: ACK45656.1.
RefSeqiWP_012587040.1. NC_011663.1.
YP_002357079.1. NC_011663.1.

Genome annotation databases

EnsemblBacteriaiACK45656; ACK45656; Sbal223_1141.
GeneIDi7087594.
KEGGisbp:Sbal223_1141.
PATRICi23478352. VBISheBal125792_1181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001252 Genomic DNA. Translation: ACK45656.1 .
RefSeqi WP_012587040.1. NC_011663.1.
YP_002357079.1. NC_011663.1.

3D structure databases

ProteinModelPortali B8E6P5.
SMRi B8E6P5. Positions 1-438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 407976.Sbal223_1141.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK45656 ; ACK45656 ; Sbal223_1141 .
GeneIDi 7087594.
KEGGi sbp:Sbal223_1141.
PATRICi 23478352. VBISheBal125792_1181.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000047313.
KOi K00758.
OMAi FINGVRD.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

UniPathwayi UPA00578 ; UER00638 .
BioCyci SBAL407976:GJ6Y-1173-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_01628. Thymid_phosp.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS223.

Entry informationi

Entry nameiTYPH_SHEB2
AccessioniPrimary (citable) accession number: B8E6P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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