B8E6P4 (DEOC_SHEB2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	Sbal223_1140

Organism

Shewanella baltica (strain OS223) [Complete proteome] [HAMAP]

Taxonomic identifier

407976 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00592
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00592
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00592
Subcellular location	Cytoplasm By similarity HAMAP MF_00592.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Deoxyribose-phosphate aldolase HAMAP MF_00592		PRO_1000146965
Sites
	Active site	165	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	197	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8E6P4 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: DFB6566C9B47161F	FASTA	256	27,345
	10 20 30 40 50 60 MTDLKKAAQR AIELMDLTTL NDDDTDQKVI DLCHKAKTAA GNTAAICIYP RFIPIARKTL 70 80 90 100 110 120 DEIGAEDIQI ATVTNFPHGN DDIAIAVLET RAAVAYGADE VDVVFPYRAL MEGNETIGFE 130 140 150 160 170 180 LVKACKEACG EVLLKVIIES GVLADPALIR RASELSIDAG ADFIKTSTGK VPVNATLEAA 190 200 210 220 230 240 EIMLTVISEK NTQVGFKPAG GVRDAAQAAE FLGVAERILG ADWVSPRTFR FGASSLLNSL 250 LHTLELADAP KPTQGY

References

[1]

"Complete sequence of chromosome of Shewanella baltica OS223." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L. , Kyrpides N., Ovchinnikova G., Brettar I., Rodrigues J., Konstantinidis K., Tiedje J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS223.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001252 Genomic DNA. Translation: ACK45655.1.
RefSeq	YP_002357078.1. NC_011663.1.
3D structure databases
ProteinModelPortal	B8E6P4.
SMR	B8E6P4. Positions 1-232.
ModBase	Search...
Protein-protein interaction databases
STRING	B8E6P4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7087593.
GenomeReviews	Gene locus Sbal223_1140 in contig CP001252_GR.
KEGG	sbp:Sbal223_1140.
PATRIC	23478350. VBISheBal125792_1180.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG636421.
OMA	ELVQQCK.
ProtClustDB	PRK05283.
Family and domain databases
HAMAP	MF_00592. DeoC_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR023649. DeoC_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_SHEB2

Accession

Primary (citable) accession number: B8E6P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program