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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Shewanella baltica (strain OS223)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi20 – 201Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi23 – 231Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi100 – 1001Iron-sulfur (4Fe-4S)UniRule annotation
Binding sitei225 – 2251S-adenosyl-L-methionineUniRule annotation
Binding sitei254 – 2541S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei275 – 2751S-adenosyl-L-methionineUniRule annotation
Binding sitei322 – 3221S-adenosyl-L-methionineUniRule annotation
Active sitei349 – 3491NucleophileUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSBAL407976:GJ6Y-3534-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Synonyms:rumB
Ordered Locus Names:Sbal223_3424
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002507 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 39039023S rRNA (uracil(747)-C(5))-methyltransferase RlmCPRO_1000148897Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB8E5Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218547.
KOiK03212.
OMAiNIQPIHM.
OrthoDBiEOG6V4GKM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC.
InterProiIPR001566. 23S_rRNA_MeTrfase_RlmD.
IPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
TIGR00479. rumA. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8E5Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAIVNAVK QCGYFNQGQC LSCRHIQQPL AQQVAVKTQT LLQLLAPFIP
60 70 80 90 100
ANSAELFLPP ITGDDSGFRN KAKMVVLGAA HEPVLGIVSP SGEAVDLCDC
110 120 130 140 150
LLYPADMQAL LHRLTRFVQQ AGLPPYRVDK AKGELKFILL TRSQVRGEYL
160 170 180 190 200
LRFVLRSHNG IERIERELPA LLAEYPQIKV VSVNIQPVHM AILEGDEEIF
210 220 230 240 250
LTENTRLEER FNHVPLFIRP KSFFQTNPQV AAQLYQTARE WVAEFSPRSL
260 270 280 290 300
WDLFCGVGGF GLHCASKDIT LTGIEIEAEA IACAQMSAQM MGLENVQFMA
310 320 330 340 350
LDSTDFAKGK SAADKPDLII VNPPRRGIGE ALCQSLSEFA PKAILYSSCN
360 370 380 390
PKTLAKDLEH IQGYHLTKVQ LFDLFPHTDH FEVLAMLVKD
Length:390
Mass (Da):43,329
Last modified:March 3, 2009 - v1
Checksum:i0F71D866BF95208F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA. Translation: ACK47908.1.
RefSeqiWP_006083989.1. NC_011663.1.

Genome annotation databases

EnsemblBacteriaiACK47908; ACK47908; Sbal223_3424.
GeneIDi11773650.
KEGGisbp:Sbal223_3424.
sbt:Sbal678_3642.
PATRICi23483233. VBISheBal125792_3538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA. Translation: ACK47908.1.
RefSeqiWP_006083989.1. NC_011663.1.

3D structure databases

ProteinModelPortaliB8E5Q5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK47908; ACK47908; Sbal223_3424.
GeneIDi11773650.
KEGGisbp:Sbal223_3424.
sbt:Sbal678_3642.
PATRICi23483233. VBISheBal125792_3538.

Phylogenomic databases

HOGENOMiHOG000218547.
KOiK03212.
OMAiNIQPIHM.
OrthoDBiEOG6V4GKM.

Enzyme and pathway databases

BioCyciSBAL407976:GJ6Y-3534-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC.
InterProiIPR001566. 23S_rRNA_MeTrfase_RlmD.
IPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
TIGR00479. rumA. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS223.

Entry informationi

Entry nameiRLMC_SHEB2
AccessioniPrimary (citable) accession number: B8E5Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 11, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.