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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Shewanella baltica (strain OS223)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAL407976:G1GU6-1137-MONOMER.
UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:Sbal223_1095
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002507 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001253601 – 216Probable nicotinate-nucleotide adenylyltransferaseAdd BLAST216

Structurei

3D structure databases

SMRiB8E4X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262781.
KOiK00969.
OMAiIHIGHLI.

Family and domain databases

CDDicd02165. NMNAT. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiView protein in InterPro
IPR004821. Cyt_trans-like.
IPR005248. NadD/NMNAT.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF01467. CTP_transf_like. 1 hit.
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

B8E4X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIGILGGTF DPIHYGHIRP AIEVKHALAL DKILLMPNHI PPHKQQPNLT
60 70 80 90 100
TAQRLNMVAD VCSQLDGFEL CDIEAKRDTP SYTVVTLEQL KALHPEDELF
110 120 130 140 150
FIMGMDSFLQ LKSWYEWQRL FNFAHLVVCQ RPGWQLDAAH PMQQILTARS
160 170 180 190 200
HAHQETHEGH AKNTHKNSGQ IFPVTITPQD ISSTQIREQL AKGEIPADLL
210
MPITLDYIQN QRLYLP
Length:216
Mass (Da):24,696
Last modified:March 3, 2009 - v1
Checksum:i507B852DC78F2CAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA. Translation: ACK45610.1.
RefSeqiWP_012587017.1. NC_011663.1.

Genome annotation databases

EnsemblBacteriaiACK45610; ACK45610; Sbal223_1095.
KEGGisbp:Sbal223_1095.

Similar proteinsi

Entry informationi

Entry nameiNADD_SHEB2
AccessioniPrimary (citable) accession number: B8E4X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome