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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Shewanella baltica (strain OS223)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei327Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCobalamin biosynthesis

Enzyme and pathway databases

BioCyciSBAL407976:G1GU6-1037-MONOMER
UniPathwayiUPA00061; UER00516

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:Sbal223_0999
OrganismiShewanella baltica (strain OS223)
Taxonomic identifieri407976 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002507 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001251141 – 360Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST360

Proteomic databases

PRIDEiB8E4M8

Structurei

3D structure databases

ProteinModelPortaliB8E4M8
SMRiB8E4M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263500
KOiK00768
OMAiQMATFAE

Family and domain databases

CDDicd02439 DMB-PRT_CobT, 1 hit
Gene3Di1.10.1610.10, 2 hits
HAMAPiMF_00230 CobT, 1 hit
InterProiView protein in InterPro
IPR003200 Nict_dMeBzImd_PRibTrfase-like
IPR023195 Nict_dMeBzImd_PRibTrfase_N
IPR017846 Nict_dMeBzImd_PRibTrfase_pro
IPR036087 Nict_dMeBzImd_PRibTrfase_sf
PfamiView protein in Pfam
PF02277 DBI_PRT, 1 hit
SUPFAMiSSF52733 SSF52733, 1 hit
TIGRFAMsiTIGR03160 cobT_DBIPRT, 1 hit

Sequencei

Sequence statusi: Complete.

B8E4M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSAVSFQI SPVSKTQDPL IQQKIDLKTK PPGALGQLES LALQIARVQA
60 70 80 90 100
TDSQQTDQPQ NTVLKIVHPT MLVFAGDHGI AAEGVSIAPS EVTRQMVQNF
110 120 130 140 150
AHGGAAINVF CRQVGFTLEV IDCGILTPVE GVEGIIDQRL GAGTGAIHLE
160 170 180 190 200
PAMALETVDK GFAMARDLIE RHHQAGCNLV AFGEMGIGNT SAAAAIMAAI
210 220 230 240 250
MQLDVIDCVG RGTGINSETL ERKLMLIELA LLLHQSALTG PKSVLACLGG
260 270 280 290 300
FEIVQMTGAM LAAAERKMLV VVDGFIATAA ALVAVQIAPN VRDYLIFAHQ
310 320 330 340 350
SDEQGHQRML EFLQAKPLLS LGLRLGEGTG AALALPLIQA SVNFYNQMAS
360
FSDAGIEAVV
Length:360
Mass (Da):37,954
Last modified:March 3, 2009 - v1
Checksum:iC58738537D521A27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001252 Genomic DNA Translation: ACK45514.1
RefSeqiWP_012586951.1, NC_011663.1

Genome annotation databases

EnsemblBacteriaiACK45514; ACK45514; Sbal223_0999
KEGGisbp:Sbal223_0999

Entry informationi

Entry nameiCOBT_SHEB2
AccessioniPrimary (citable) accession number: B8E4M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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