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B8E3R2 (B8E3R2_SHEB2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-ketoacyl-CoA thiolase HAMAP MF_01620
EC=2.3.1.16 HAMAP MF_01620
Alternative name(s):
Acetyl-CoA acyltransferase HAMAP MF_01620
Beta-ketothiolase HAMAP MF_01620
Fatty acid oxidation complex subunit beta HAMAP MF_01620
Gene names
Name:fadA HAMAP MF_01620
Ordered Locus Names:Sbal223_0019
OrganismShewanella baltica (strain OS223) [Complete proteome] [HAMAP]
Taxonomic identifier407976 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed By similarity. HAMAP MF_01620

Catalytic activity

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. HAMAP MF_01620 SAAS SAAS020613

Pathway

Lipid metabolism; fatty acid beta-oxidation. HAMAP MF_01620 SAAS SAAS020613

Subunit structure

Heterotetramer of two alpha chains (fadB) and two beta chains (fadA) By similarity. HAMAP MF_01620 SAAS SAAS020613

Subcellular location

Cytoplasm By similarity HAMAP MF_01620.

Sequence similarities

Belongs to the thiolase family. HAMAP MF_01620

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site911Acyl-thioester intermediate By similarity HAMAP MF_01620
Active site3431Proton acceptor By similarity HAMAP MF_01620
Active site3731Proton acceptor By similarity HAMAP MF_01620

Sequences

Sequence LengthMass (Da)Tools
B8E3R2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: D8BE5A3984D9C175

FASTA38740,576
        10         20         30         40         50         60 
MKQAVIVDCI RTPMGRSKAG VFRNVRAETL SAELMKGLLL RNPQLDPNLI EDVIWGCVQQ 

        70         80         90        100        110        120 
TLEQGFNIAR NASLLAGIPK TAGAVTVNRL CGSSMDAIHQ AARAIMTGMG DTFIIGGVEH 

       130        140        150        160        170        180 
MGHVPMSHGV DFHPGLANNV AKASGMMGLT AEMLGKLHGI TREQQDAFAV RSHQRAYAAT 

       190        200        210        220        230        240 
VEGRFAKEIY GIEGHDANGA LIKVLQDEVI RPETTMESLA ALRPVFDPVN GTVTAGTSSA 

       250        260        270        280        290        300 
LSDGASAMLI MEESKARALG LPIRARIRSM AVAGCDAAIM GYGPVPATQK ALARAGITVA 

       310        320        330        340        350        360 
DLDVIELNEA FAAQSLPCVK DLGLADVVDD KINLNGGAIA LGHPLGCSGA RISTTLINLM 

       370        380 
EDKDATLGLA TMCIGLGQGI ATVFERV

« Hide

References

[1]"Complete sequence of chromosome of Shewanella baltica OS223."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Ovchinnikova G., Brettar I., Rodrigues J., Konstantinidis K., Tiedje J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OS223.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001252 Genomic DNA. Translation: ACK44563.1.
RefSeqYP_002355986.1. NC_011663.1.

3D structure databases

ProteinModelPortalB8E3R2.
SMRB8E3R2. Positions 2-387.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8E3R2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7089231.
GenomeReviewsGene locus Sbal223_0019 in contig CP001252_GR.
KEGGsbp:Sbal223_0019.
PATRIC23475964. VBISheBal125792_0020.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG370930.
OMASSMEAIH.
ProtClustDBPRK08947.

Family and domain databases

HAMAPMF_01620. FadA.
[Tree]
InterProIPR012805. FadA.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 4 hits.
KOK00632.
PANTHERPTHR18919:SF35. PTHR18919:SF35. 1 hit.
PTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02445. FadA. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8E3R2_SHEB2
AccessionPrimary (citable) accession number: B8E3R2
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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