B8E336 (B8E336_DICTD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	Dtur_1637

Organism

Dictyoglomus turgidum (strain Z-1310 / DSM 6724)

Taxonomic identifier

515635 [NCBI]

Taxonomic lineage

Bacteria › Dictyoglomi › Dictyoglomales › Dictyoglomaceae › Dictyoglomus

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ACK42910.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	53 – 60	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B8E336 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 87EFDBED5731F3D0	FASTA	544	59,821
	10 20 30 40 50 60 MKRILEVVLE LGIPEEFFIP YGWYVGKVKW NYYKEIQNNP SGKLILVSAM NPTPYGEGKT 70 80 90 100 110 120 TTTIGLGDAI RRLSYRSFVC IREPSMGPVF GIKGGAVGGG KAKVVPEDII NLHFTGDIHA 130 140 150 160 170 180 VTSAHNLLSA LIDNHIYHGN ELSIDVRQIF WKRCLDMNDR QLRFIVSGLG GRANGIPRED 190 200 210 220 230 240 GFDITAASEV MAIISLSRNI SELKERLGNI VIGINKNGMP VLCKDIGAQG SMSVVLKDAI 250 260 270 280 290 300 SPNLVQTLEG TPAFVHGGPF ANIAHGANSL IATEMALKLS DYVITEAGFG VDLGAEKFFN 310 320 330 340 350 360 IKCRLGNIKP SAVVIVVSVR ALKFHGGIKK DLEGENIEAI KKGLPNLLHH VDVIRDVFKL 370 380 390 400 410 420 PVVVALNRFP KDSEREIEYV LSELRDRNIR VAISEVYEKG GLGGIQLAQE VIKAIEEDKN 430 440 450 460 470 480 EFSYLYDLNE SYKDKIDKIC KRVYGAREVI FSESAKEDLK RIESWGFVNL PVCMAKTQYS 490 500 510 520 530 540 LSDNPKLLGR PEDFVINVQG VKISGGAGFL VVYTGNIMTM PGLPKVPSAY NMDLDENGNI IGLL

References

[1]

"Complete sequence of Dictyoglomus turgidum DSM 6724." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z-1310 / DSM 6724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001251 Genomic DNA. Translation: ACK42910.1.
RefSeq	YP_002353524.1. NC_011661.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8E336.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7082155.
GenomeReviews	Gene locus Dtur_1637 in contig CP001251_GR.
KEGG	dtu:Dtur_1637.
PATRIC	21812080. VBIDicTur93964_1686.
Phylogenomic databases
HOGENOM	HBG677721.
OMA	TDFTVTI.
ProtClustDB	CLSK2410079.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8E336_DICTD

Accession

Primary (citable) accession number: B8E336

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)