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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciDTUR515635:G1GU5-1284-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Dtur_1250
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi
  • UP000007719 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei47 – 67HelicalUniRule annotationAdd BLAST21
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Transmembranei105 – 125HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 157HelicalUniRule annotationAdd BLAST21
Transmembranei162 – 182HelicalUniRule annotationAdd BLAST21
Transmembranei186 – 206HelicalUniRule annotationAdd BLAST21
Transmembranei210 – 230HelicalUniRule annotationAdd BLAST21
Transmembranei237 – 257HelicalUniRule annotationAdd BLAST21
Transmembranei285 – 305HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001165111 – 307Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST307

Interactioni

Protein-protein interaction databases

STRINGi515635.Dtur_1250

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
InParanoidiB8E328
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8E328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIILFTSLV AFFVFLLILK YWINFQKSKG IGKYIRKEGP SSHFQKSGTP
60 70 80 90 100
VMGGIIFLIV SIPFLFFKET FFPSLSTILF GLLGLLDDFK LMVNKDYGIR
110 120 130 140 150
PLRKIFLSFI ITLLLYIFSF HDYKIYWGSK LIISSRIFYV ILFFVVFIAV
160 170 180 190 200
PNAINLTDGL DGLAGGTSLI TLFFFLIYNF QFNNELTLEI SLMITALIAF
210 220 230 240 250
LWFNSHPAEI FMGDVGAFAL GGFIASLSII NKVELLLVFL GGIFLIESLS
260 270 280 290 300
VFIQVFFYKW KKRRVFLMSP LHHHFELKGW KETKVVWRFY IIHLIMMIGG

IILWNLT
Length:307
Mass (Da):35,486
Last modified:March 3, 2009 - v1
Checksum:i44CE2FD85A8A6B91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA Translation: ACK42528.1
RefSeqiWP_012583610.1, NC_011661.1
YP_002353142.1, NC_011661.1

Genome annotation databases

EnsemblBacteriaiACK42528; ACK42528; Dtur_1250
GeneIDi7082732
KEGGidtu:Dtur_1250
PATRICifig|515635.4.peg.1290

Similar proteinsi

Entry informationi

Entry nameiMRAY_DICTD
AccessioniPrimary (citable) accession number: B8E328
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: February 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health