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B8E2S5

- PNP_DICTD

UniProt

B8E2S5 - PNP_DICTD

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Dtur_1146
Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi485 – 4851Magnesium By similarity
Metal bindingi491 – 4911Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDTUR515635:GH4F-1172-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Dtur_1146
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
ProteomesiUP000007719: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000185736Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515635.Dtur_1146.

Structurei

3D structure databases

ProteinModelPortaliB8E2S5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 61160KH
Add
BLAST
Domaini621 – 69171S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8E2S5-1 [UniParc]FASTAAdd to Basket

« Hide

MRQTYSFKKD FAGKTLKIDI GKVAWQATGA ALVQYGETTV LVTVVASEEK    50
KEDVDFFPLT VEYVERLYAA GKIPGGFFKR EGKPTEPEIL FARLIDRPLR 100
PLFSKDFRNE VQVIVTVLSY DHENSTDIPS IIGASCAIML AGLPFKGPIG 150
AVRVGWDGKE WYINPSVALS NSLLLDLVVA GTKDAVLMIE GDGKEVPEEI 200
FLEGIIRAHE QIGEVINFQE EILSMVNPVP FNYEPFVVNE NLKKDVLEYV 250
TVDQIRDAIF TPSKSERQKA LEDLKKRVIE HFKPIYGEIT AQIDEIINQE 300
AKAILTKVIL EEKRRVDGRR LNELRPVSCE VGVLSRVHGS ALFQRGETQV 350
LSVVTLGAGE EQIIESVIES EPKRYIHHYN FPPFSVGEAK PLRGPKRREI 400
GHGALAERAL LPLIPKEEEF PYTIRVVSEV LSSNGSTSMA SVCGSSLSLM 450
DAGVPIKTHV AGVAMGLIKE GEKFEVLTDI QGLEDALGGM DFKIAGTKNG 500
ITAVQLDIKV DGLSYEIIEK TLKQAKEARY QILDIMEKTI SQPRPEISPY 550
APRIMVLEIN PNKIGDLIGP SGKNIKKIIE ETHTTINIKP EGLVYISAPD 600
QESAEKAAQM VQEYTRDIKE GDIFLGKVIR VTDYGAFVEI LPGKIGLLHI 650
SKYKTTGTGK NQTREEINLG DEILIKVDSI DPSGRISLSR KDL 693
Length:693
Mass (Da):76,821
Last modified:March 3, 2009 - v1
Checksum:iA0F962C980F2976D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001251 Genomic DNA. Translation: ACK42425.1.
RefSeqiYP_002353039.1. NC_011661.1.

Genome annotation databases

EnsemblBacteriaiACK42425; ACK42425; Dtur_1146.
GeneIDi7082621.
KEGGidtu:Dtur_1146.
PATRICi21811026. VBIDicTur93964_1183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001251 Genomic DNA. Translation: ACK42425.1 .
RefSeqi YP_002353039.1. NC_011661.1.

3D structure databases

ProteinModelPortali B8E2S5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515635.Dtur_1146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK42425 ; ACK42425 ; Dtur_1146 .
GeneIDi 7082621.
KEGGi dtu:Dtur_1146.
PATRICi 21811026. VBIDicTur93964_1183.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DTUR515635:GH4F-1172-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-1310 / DSM 6724.

Entry informationi

Entry nameiPNP_DICTD
AccessioniPrimary (citable) accession number: B8E2S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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