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B8E2S5

- PNP_DICTD

UniProt

B8E2S5 - PNP_DICTD

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi485 – 4851MagnesiumUniRule annotation
Metal bindingi491 – 4911MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDTUR515635:GH4F-1172-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Dtur_1146
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
ProteomesiUP000007719: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Polyribonucleotide nucleotidyltransferasePRO_1000185736Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515635.Dtur_1146.

Structurei

3D structure databases

ProteinModelPortaliB8E2S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 61160KHUniRule annotationAdd
BLAST
Domaini621 – 69171S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
InParanoidiB8E2S5.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8E2S5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQTYSFKKD FAGKTLKIDI GKVAWQATGA ALVQYGETTV LVTVVASEEK
60 70 80 90 100
KEDVDFFPLT VEYVERLYAA GKIPGGFFKR EGKPTEPEIL FARLIDRPLR
110 120 130 140 150
PLFSKDFRNE VQVIVTVLSY DHENSTDIPS IIGASCAIML AGLPFKGPIG
160 170 180 190 200
AVRVGWDGKE WYINPSVALS NSLLLDLVVA GTKDAVLMIE GDGKEVPEEI
210 220 230 240 250
FLEGIIRAHE QIGEVINFQE EILSMVNPVP FNYEPFVVNE NLKKDVLEYV
260 270 280 290 300
TVDQIRDAIF TPSKSERQKA LEDLKKRVIE HFKPIYGEIT AQIDEIINQE
310 320 330 340 350
AKAILTKVIL EEKRRVDGRR LNELRPVSCE VGVLSRVHGS ALFQRGETQV
360 370 380 390 400
LSVVTLGAGE EQIIESVIES EPKRYIHHYN FPPFSVGEAK PLRGPKRREI
410 420 430 440 450
GHGALAERAL LPLIPKEEEF PYTIRVVSEV LSSNGSTSMA SVCGSSLSLM
460 470 480 490 500
DAGVPIKTHV AGVAMGLIKE GEKFEVLTDI QGLEDALGGM DFKIAGTKNG
510 520 530 540 550
ITAVQLDIKV DGLSYEIIEK TLKQAKEARY QILDIMEKTI SQPRPEISPY
560 570 580 590 600
APRIMVLEIN PNKIGDLIGP SGKNIKKIIE ETHTTINIKP EGLVYISAPD
610 620 630 640 650
QESAEKAAQM VQEYTRDIKE GDIFLGKVIR VTDYGAFVEI LPGKIGLLHI
660 670 680 690
SKYKTTGTGK NQTREEINLG DEILIKVDSI DPSGRISLSR KDL
Length:693
Mass (Da):76,821
Last modified:March 3, 2009 - v1
Checksum:iA0F962C980F2976D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA. Translation: ACK42425.1.
RefSeqiYP_002353039.1. NC_011661.1.

Genome annotation databases

EnsemblBacteriaiACK42425; ACK42425; Dtur_1146.
GeneIDi7082621.
KEGGidtu:Dtur_1146.
PATRICi21811026. VBIDicTur93964_1183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA. Translation: ACK42425.1 .
RefSeqi YP_002353039.1. NC_011661.1.

3D structure databases

ProteinModelPortali B8E2S5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515635.Dtur_1146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK42425 ; ACK42425 ; Dtur_1146 .
GeneIDi 7082621.
KEGGi dtu:Dtur_1146.
PATRICi 21811026. VBIDicTur93964_1183.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
InParanoidi B8E2S5.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DTUR515635:GH4F-1172-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-1310 / DSM 6724.

Entry informationi

Entry nameiPNP_DICTD
AccessioniPrimary (citable) accession number: B8E2S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3