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B8E2K1 (PYRF_DICTD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:Dtur_1571
OrganismDictyoglomus turgidum (strain Z-1310 / DSM 6724) [Reference proteome] [HAMAP]
Taxonomic identifier515635 [NCBI]
Taxonomic lineageBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_1000164567

Regions

Region61 – 7010Substrate binding By similarity

Sites

Active site631Proton donor By similarity
Binding site121Substrate By similarity
Binding site341Substrate By similarity
Binding site1251Substrate By similarity
Binding site1871Substrate By similarity
Binding site1961Substrate By similarity
Binding site2161Substrate; via amide nitrogen By similarity
Binding site2171Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B8E2K1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 4BB3B1F3718D9635

FASTA24427,981
        10         20         30         40         50         60 
MRKYYPIIVA LDFPEEKRAL EIAEKLVPYI KNFKVGLELF SVAGPHIVKA LKEMGTNVFI 

        70         80         90        100        110        120 
DLKLFDIPNT VVRTLDRLLA LEPFMVTLHI LGGEEMLRES VKLVSQYKES NKTEYPYLLG 

       130        140        150        160        170        180 
VTVLTSFNEE TLRRSWGISR SLPEQVLFLA QLAQETGLDG VIASPWEIEL LRNNLKRPML 

       190        200        210        220        230        240 
IVTPGIRLTK EKTDDQQRIM TPREALERGS DYLVIGRPIT QSPDPYEVIQ NIRSQIEDIV 


ESRL 

« Hide

References

[1]"Complete sequence of Dictyoglomus turgidum DSM 6724."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-1310 / DSM 6724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001251 Genomic DNA. Translation: ACK42845.1.
RefSeqYP_002353459.1. NC_011661.1.

3D structure databases

ProteinModelPortalB8E2K1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING515635.Dtur_1571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK42845; ACK42845; Dtur_1571.
GeneID7082006.
KEGGdtu:Dtur_1571.
PATRIC21811944. VBIDicTur93964_1619.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226071.
KOK01591.
OMAVIASPWE.
OrthoDBEOG6N6815.

Enzyme and pathway databases

BioCycDTUR515635:GH4F-1620-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_DICTD
AccessionPrimary (citable) accession number: B8E2K1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways