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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciDTUR515635:G1GU5-1566-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Dtur_1517
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi
  • UP000007719 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001479851 – 453Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST453

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi515635.Dtur_1517

Structurei

3D structure databases

ProteinModelPortaliB8E2E7
SMRiB8E2E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEM Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
InParanoidiB8E2E7
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B8E2E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYFPHTPQE IREMLNTIGV DSIEELFSEI PEEIRQKAKE NFKLSASPSE
60 70 80 90 100
IDLLEEIKQI SKKNIGKDYI SFLGGGAYRH YIPSFVKLVS LFPTFYTSYT
110 120 130 140 150
PYQPEISQGV LQSIFEYQSL ICDLTGMEVA NASLYEAGSG IAEAALMSVR
160 170 180 190 200
ITGKKEVIVS SGLNPEYISV LKTYLQVQNI DLKILPLDEN GETDITALER
210 220 230 240 250
TISPSTSGVI LQNPNFFGVI ETKLKEMETL IHKNNALFIL SIYPISLGIL
260 270 280 290 300
KPPSEYNVDI VVGEGQSLGI PLGFGGPYLG ILATKKEFIR QIPGRIVGET
310 320 330 340 350
IDLEGERGFV NTLQTREQHI RRAKATSNIC TNEALSAISA AVYMALLGKK
360 370 380 390 400
GIKKIAEVCF SRAHYLKDRL QKKLGIDFIY PNSYFFNEFV IKTPENSKVF
410 420 430 440 450
LKKLEERKIL GGIPLSKFYK EREKEILIAV TERNSIEEID YYVKSLKEVL

KKD
Length:453
Mass (Da):50,912
Last modified:March 3, 2009 - v1
Checksum:i3E381E07BC2054D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA Translation: ACK42791.1
RefSeqiWP_012583867.1, NC_011661.1
YP_002353405.1, NC_011661.1

Genome annotation databases

EnsemblBacteriaiACK42791; ACK42791; Dtur_1517
GeneIDi7081952
KEGGidtu:Dtur_1517
PATRICifig|515635.4.peg.1566

Similar proteinsi

Entry informationi

Entry nameiGCSPA_DICTD
AccessioniPrimary (citable) accession number: B8E2E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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