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B8E2E7

- GCSPA_DICTD

UniProt

B8E2E7 - GCSPA_DICTD

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciDTUR515635:GH4F-1566-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Dtur_1517
    OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
    Taxonomic identifieri515635 [NCBI]
    Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
    ProteomesiUP000007719: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000147985Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi515635.Dtur_1517.

    Structurei

    3D structure databases

    ProteinModelPortaliB8E2E7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiYVRKIPG.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8E2E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYFPHTPQE IREMLNTIGV DSIEELFSEI PEEIRQKAKE NFKLSASPSE    50
    IDLLEEIKQI SKKNIGKDYI SFLGGGAYRH YIPSFVKLVS LFPTFYTSYT 100
    PYQPEISQGV LQSIFEYQSL ICDLTGMEVA NASLYEAGSG IAEAALMSVR 150
    ITGKKEVIVS SGLNPEYISV LKTYLQVQNI DLKILPLDEN GETDITALER 200
    TISPSTSGVI LQNPNFFGVI ETKLKEMETL IHKNNALFIL SIYPISLGIL 250
    KPPSEYNVDI VVGEGQSLGI PLGFGGPYLG ILATKKEFIR QIPGRIVGET 300
    IDLEGERGFV NTLQTREQHI RRAKATSNIC TNEALSAISA AVYMALLGKK 350
    GIKKIAEVCF SRAHYLKDRL QKKLGIDFIY PNSYFFNEFV IKTPENSKVF 400
    LKKLEERKIL GGIPLSKFYK EREKEILIAV TERNSIEEID YYVKSLKEVL 450
    KKD 453
    Length:453
    Mass (Da):50,912
    Last modified:March 3, 2009 - v1
    Checksum:i3E381E07BC2054D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001251 Genomic DNA. Translation: ACK42791.1.
    RefSeqiWP_012583867.1. NC_011661.1.
    YP_002353405.1. NC_011661.1.

    Genome annotation databases

    EnsemblBacteriaiACK42791; ACK42791; Dtur_1517.
    GeneIDi7081952.
    KEGGidtu:Dtur_1517.
    PATRICi21811838. VBIDicTur93964_1566.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001251 Genomic DNA. Translation: ACK42791.1 .
    RefSeqi WP_012583867.1. NC_011661.1.
    YP_002353405.1. NC_011661.1.

    3D structure databases

    ProteinModelPortali B8E2E7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515635.Dtur_1517.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK42791 ; ACK42791 ; Dtur_1517 .
    GeneIDi 7081952.
    KEGGi dtu:Dtur_1517.
    PATRICi 21811838. VBIDicTur93964_1566.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi YVRKIPG.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci DTUR515635:GH4F-1566-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z-1310 / DSM 6724.

    Entry informationi

    Entry nameiGCSPA_DICTD
    AccessioniPrimary (citable) accession number: B8E2E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3