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B8E2E7

- GCSPA_DICTD

UniProt

B8E2E7 - GCSPA_DICTD

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciDTUR515635:GH4F-1566-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Dtur_1517
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
ProteomesiUP000007719: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000147985Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi515635.Dtur_1517.

Structurei

3D structure databases

ProteinModelPortaliB8E2E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
InParanoidiB8E2E7.
KOiK00282.
OMAiYVRKIPG.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B8E2E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYFPHTPQE IREMLNTIGV DSIEELFSEI PEEIRQKAKE NFKLSASPSE
60 70 80 90 100
IDLLEEIKQI SKKNIGKDYI SFLGGGAYRH YIPSFVKLVS LFPTFYTSYT
110 120 130 140 150
PYQPEISQGV LQSIFEYQSL ICDLTGMEVA NASLYEAGSG IAEAALMSVR
160 170 180 190 200
ITGKKEVIVS SGLNPEYISV LKTYLQVQNI DLKILPLDEN GETDITALER
210 220 230 240 250
TISPSTSGVI LQNPNFFGVI ETKLKEMETL IHKNNALFIL SIYPISLGIL
260 270 280 290 300
KPPSEYNVDI VVGEGQSLGI PLGFGGPYLG ILATKKEFIR QIPGRIVGET
310 320 330 340 350
IDLEGERGFV NTLQTREQHI RRAKATSNIC TNEALSAISA AVYMALLGKK
360 370 380 390 400
GIKKIAEVCF SRAHYLKDRL QKKLGIDFIY PNSYFFNEFV IKTPENSKVF
410 420 430 440 450
LKKLEERKIL GGIPLSKFYK EREKEILIAV TERNSIEEID YYVKSLKEVL

KKD
Length:453
Mass (Da):50,912
Last modified:March 3, 2009 - v1
Checksum:i3E381E07BC2054D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001251 Genomic DNA. Translation: ACK42791.1.
RefSeqiWP_012583867.1. NC_011661.1.
YP_002353405.1. NC_011661.1.

Genome annotation databases

EnsemblBacteriaiACK42791; ACK42791; Dtur_1517.
GeneIDi7081952.
KEGGidtu:Dtur_1517.
PATRICi21811838. VBIDicTur93964_1566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001251 Genomic DNA. Translation: ACK42791.1 .
RefSeqi WP_012583867.1. NC_011661.1.
YP_002353405.1. NC_011661.1.

3D structure databases

ProteinModelPortali B8E2E7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515635.Dtur_1517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK42791 ; ACK42791 ; Dtur_1517 .
GeneIDi 7081952.
KEGGi dtu:Dtur_1517.
PATRICi 21811838. VBIDicTur93964_1566.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
InParanoidi B8E2E7.
KOi K00282.
OMAi YVRKIPG.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci DTUR515635:GH4F-1566-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-1310 / DSM 6724.

Entry informationi

Entry nameiGCSPA_DICTD
AccessioniPrimary (citable) accession number: B8E2E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3