B8E290 (B8E290_DICTD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit HAMAP MF_00444 RuleBase RU003567
EC=3.4.21.92 HAMAP MF_00444 RuleBase RU000549

Alternative name(s):
Endopeptidase Clp HAMAP MF_00444

Gene names

Name:	clpP HAMAP MF_00444
Ordered Locus Names:	Dtur_1088

Organism

Dictyoglomus turgidum (strain Z-1310 / DSM 6724)

Taxonomic identifier

515635 [NCBI]

Taxonomic lineage

Bacteria › Dictyoglomi › Dictyoglomales › Dictyoglomaceae › Dictyoglomus

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444 RuleBase RU000550
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444 RuleBase RU000549
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP MF_00444 RuleBase RU003567

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444 RuleBase RU000549
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	97	1	By similarity HAMAP MF_00444
	Active site	122	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	B8E290 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: A10D2E5CDCE95A37	FASTA	194	21,599
	10 20 30 40 50 60 MLVPIVIEQT PRGERAYDIY SRLLKSRIVF LGTTINDEVA NLIVAQLLFL ESEDPEKDIY 70 80 90 100 110 120 LYINSPGGEV SAGLAIYDTI RHIKPKVATV CVGQAASMAA ILLAAGDKGK RYALPHSRVM 130 140 150 160 170 180 IHQPLGGAYG PAADIEIHTR EILKIKRVLN EILAYHTGQP IEKIEKDTDR DFFMSAYEAK 190 EYGIVDEVLE SKKE

References

[1]

"Complete sequence of Dictyoglomus turgidum DSM 6724." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z-1310 / DSM 6724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001251 Genomic DNA. Translation: ACK42367.1.
RefSeq	YP_002352981.1. NC_011661.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8E290.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7083039.
GenomeReviews	Gene locus Dtur_1088 in contig CP001251_GR.
KEGG	dtu:Dtur_1088.
PATRIC	21810908. VBIDicTur93964_1124.
Phylogenomic databases
HOGENOM	HBG558421.
OMA	ELMAKHT.
PhylomeDB	B8E290.
ProtClustDB	CLSK2409936.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. ClpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8E290_DICTD

Accession

Primary (citable) accession number: B8E290

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)