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B8E194 (B8E194_DICTD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:Dtur_0941
OrganismDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifier515635 [NCBI]
Taxonomic lineageBacteria › Dictyoglomi › Dictyoglomales › Dictyoglomaceae › Dictyoglomus

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region253 – 2575ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2521 By similarity HAMAP MF_01815
Active site2821 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B8E194 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: C9421AF584245F01

FASTA32835,208
        10         20         30         40         50         60 
MGVGIIGIGT AVPSRVLTNF DLEKMVDTSD EWITTRTGIK ERRIADNKTT PSDLGAEAAL 

        70         80         90        100        110        120 
KAIEMAKISP EEIDLIIVTS ASLEMVFPSM AAIIQNKIGA KNAGGFDLLS ACTGFVSSVI 

       130        140        150        160        170        180 
TGAQFIRTGD VKTVLVIGTE VLSRFIDWED RNTCVLFGDG AGAVILREVG DNYGLLSWSL 

       190        200        210        220        230        240 
HLDGSGADLL AIPGGCAKYP CSEEVLKNKL HYIKMNGREV FKFSVRVIGE VTEEALSKAG 

       250        260        270        280        290        300 
LSSKDLNWLV PHQANIRIIE AGAERLGIPL DKVAINLQKY GNTSTASIPL ALEELIKEKK 

       310        320 
LKDGDIVALV GFGAGLSWGS AVMRWKEI

« Hide

References

[1]"Complete sequence of Dictyoglomus turgidum DSM 6724."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-1310 / DSM 6724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001251 Genomic DNA. Translation: ACK42222.1.
RefSeqYP_002352836.1. NC_011661.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8E194.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7082898.
GenomeReviewsGene locus Dtur_0941 in contig CP001251_GR.
KEGGdtu:Dtur_0941.
PATRIC21810586. VBIDicTur93964_0978.

Phylogenomic databases

HOGENOMHBG649927.
OMAMAKISPE.
PhylomeDBB8E194.
ProtClustDBCLSK2409913.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8E194_DICTD
AccessionPrimary (citable) accession number: B8E194
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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