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B8E0X7

- DEF_DICTD

UniProt

B8E0X7 - DEF_DICTD

Protein

Peptide deformylase

Gene

def

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871IronUniRule annotation
    Metal bindingi129 – 1291IronUniRule annotation
    Active sitei130 – 1301UniRule annotation
    Metal bindingi133 – 1331IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciDTUR515635:GH4F-1489-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:Dtur_1440
    OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
    Taxonomic identifieri515635 [NCBI]
    Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
    ProteomesiUP000007719: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Peptide deformylasePRO_1000200725Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515635.Dtur_1440.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243508.
    KOiK01462.
    OMAiFPARIVM.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8E0X7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMEIRKIGD PILKIKAKKV EKIDEKVKNL VRDMIETMKF SNGVGLAAPQ    50
    VGESLRIIVV DYEENPIAFI NPEILEMDGE VLDYEGCLSV PGVEVPIKRA 100
    ERIIFKAQDL QGRTKRYKAK GLLARVIQHE VDHLEGILIL DRAVEESTLA 150
    EEK 153
    Length:153
    Mass (Da):17,293
    Last modified:March 3, 2009 - v1
    Checksum:i8E70201301634A77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001251 Genomic DNA. Translation: ACK42714.1.
    RefSeqiYP_002353328.1. NC_011661.1.

    Genome annotation databases

    EnsemblBacteriaiACK42714; ACK42714; Dtur_1440.
    GeneIDi7081875.
    KEGGidtu:Dtur_1440.
    PATRICi21811680. VBIDicTur93964_1487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001251 Genomic DNA. Translation: ACK42714.1 .
    RefSeqi YP_002353328.1. NC_011661.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515635.Dtur_1440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK42714 ; ACK42714 ; Dtur_1440 .
    GeneIDi 7081875.
    KEGGi dtu:Dtur_1440.
    PATRICi 21811680. VBIDicTur93964_1487.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243508.
    KOi K01462.
    OMAi FPARIVM.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci DTUR515635:GH4F-1489-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z-1310 / DSM 6724.

    Entry informationi

    Entry nameiDEF_DICTD
    AccessioniPrimary (citable) accession number: B8E0X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3