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B8E0N9 (ASSY_DICTD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:Dtur_1787
OrganismDictyoglomus turgidum (strain Z-1310 / DSM 6724) [Reference proteome] [HAMAP]
Taxonomic identifier515635 [NCBI]
Taxonomic lineageBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_1000191893

Regions

Nucleotide binding9 – 179ATP By similarity

Sites

Binding site871Citrulline By similarity
Binding site1171ATP; via amide nitrogen By similarity
Binding site1191Aspartate By similarity
Binding site1231Aspartate By similarity
Binding site1231Citrulline By similarity
Binding site1241Aspartate By similarity
Binding site1271Citrulline By similarity
Binding site1751Citrulline By similarity
Binding site1841Citrulline By similarity
Binding site2571Citrulline By similarity
Binding site2691Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
B8E0N9 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 2883E3E95625C03B

FASTA39744,986
        10         20         30         40         50         60 
MEREKVVLAY SGGLDTSVAI KWLMQKYSLD VITLTVDIGQ GIDLNEIKNK AENLGVEKAY 

        70         80         90        100        110        120 
VLDLREEFIK DYIIPAIKSN AMYERVYPLA TALSRPLIAK YLVKVAKENG AKYVAHGCTG 

       130        140        150        160        170        180 
KGNDQVRIDL GVKALAPDLE IIAPVREWNF SREEEIEYAI ENNIPIPVSR KNPYSIDENL 

       190        200        210        220        230        240 
WGRSIEGGIL EDPWQEPPED IYLWTKLENK EPSYIEITFE KGIPVKLNGV EKDLVGLIEE 

       250        260        270        280        290        300 
LNKIAGSYGI GRIDHIENRL VGIKSREIYE APAALVIIKA HEALEDLVLP RELAHFKRML 

       310        320        330        340        350        360 
EDKYAELVYY GLWFDPFREA LQAFMDKTQE RVTGKVKIKL IPWSFSIVGR DSPYSLYDHS 

       370        380        390 
LATYDKGSTF STESAVGFIK LFGLQNYLYA LKGGKNA 

« Hide

References

[1]"Complete sequence of Dictyoglomus turgidum DSM 6724."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-1310 / DSM 6724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001251 Genomic DNA. Translation: ACK43059.1.
RefSeqYP_002353673.1. NC_011661.1.

3D structure databases

ProteinModelPortalB8E0N9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING515635.Dtur_1787.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK43059; ACK43059; Dtur_1787.
GeneID7082966.
KEGGdtu:Dtur_1787.
PATRIC21812390. VBIDicTur93964_1839.

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMAIYNGYWW.
OrthoDBEOG6K9QCV.
ProtClustDBPRK00509.

Enzyme and pathway databases

BioCycDTUR515635:GH4F-1839-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_DICTD
AccessionPrimary (citable) accession number: B8E0N9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways