Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:Dtur_1278
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi
  • UP000007719 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001922321 – 203Probable nicotinate-nucleotide adenylyltransferaseAdd BLAST203

Interactioni

Protein-protein interaction databases

STRINGi515635.Dtur_1278.

Structurei

3D structure databases

SMRiB8E0B1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262780.
InParanoidiB8E0B1.
KOiK00969.
OMAiIHIGHLI.
OrthoDBiPOG091H028Y.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiView protein in InterPro
IPR004821. Cyt_trans-like.
IPR005248. NadD/NMNAT.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF01467. CTP_transf_like. 1 hit.
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

B8E0B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIGILGGTF DPIHYGHLWF AEYAREKFKL DKVFFIPNRV PSHREIPIAT
60 70 80 90 100
SKQRYEMVLL ATLNNPYFEV LPIELEREGV SYMVDTIRDL STYFSNAELY
110 120 130 140 150
LLLGNDAFRD FLKWKDPYKI VEKVSIIVGS RGEEYYTNDL KDFIKTFENK
160 170 180 190 200
IFFLDFPYYP ISAKEIRDRV KKGLSIKYLV PENVEEYIIK NSVYCEEDQK

DVK
Length:203
Mass (Da):24,059
Last modified:March 3, 2009 - v1
Checksum:iE6C417DE1451EDD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA. Translation: ACK42556.1.
RefSeqiWP_012583638.1. NC_011661.1.
YP_002353170.1. NC_011661.1.

Genome annotation databases

EnsemblBacteriaiACK42556; ACK42556; Dtur_1278.
GeneIDi7082762.
KEGGidtu:Dtur_1278.
PATRICifig|515635.4.peg.1318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA. Translation: ACK42556.1.
RefSeqiWP_012583638.1. NC_011661.1.
YP_002353170.1. NC_011661.1.

3D structure databases

SMRiB8E0B1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi515635.Dtur_1278.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK42556; ACK42556; Dtur_1278.
GeneIDi7082762.
KEGGidtu:Dtur_1278.
PATRICifig|515635.4.peg.1318.

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262780.
InParanoidiB8E0B1.
KOiK00969.
OMAiIHIGHLI.
OrthoDBiPOG091H028Y.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiView protein in InterPro
IPR004821. Cyt_trans-like.
IPR005248. NadD/NMNAT.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF01467. CTP_transf_like. 1 hit.
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADD_DICTD
AccessioniPrimary (citable) accession number: B8E0B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: June 7, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.