B8E0B1 (NADD_DICTD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable nicotinate-nucleotide adenylyltransferase
EC=2.7.7.18

Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name=NaMN adenylyltransferase

Gene names

Name:	nadD
Ordered Locus Names:	Dtur_1278

Organism

Dictyoglomus turgidum (strain Z-1310 / DSM 6724) [Reference proteome] [HAMAP]

Taxonomic identifier

515635 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Dictyoglomi › Dictyoglomia › Dictyoglomales › Dictyoglomaceae › Dictyoglomus › Dictyoglomus turgidum

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) By similarity. HAMAP-Rule MF_00244
Catalytic activity	ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+. HAMAP-Rule MF_00244
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. HAMAP-Rule MF_00244
Sequence similarities	Belongs to the NadD family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinate-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Probable nicotinate-nucleotide adenylyltransferase HAMAP-Rule MF_00244		PRO_1000192232

Sequences

	Sequence		Length	Mass (Da)
	B8E0B1 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: E6C417DE1451EDD4	FASTA	203	24,059
	10 20 30 40 50 60 MKIGILGGTF DPIHYGHLWF AEYAREKFKL DKVFFIPNRV PSHREIPIAT SKQRYEMVLL 70 80 90 100 110 120 ATLNNPYFEV LPIELEREGV SYMVDTIRDL STYFSNAELY LLLGNDAFRD FLKWKDPYKI 130 140 150 160 170 180 VEKVSIIVGS RGEEYYTNDL KDFIKTFENK IFFLDFPYYP ISAKEIRDRV KKGLSIKYLV 190 200 PENVEEYIIK NSVYCEEDQK DVK

References

[1]

"Complete sequence of Dictyoglomus turgidum DSM 6724." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z-1310 / DSM 6724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001251 Genomic DNA. Translation: ACK42556.1.
RefSeq	YP_002353170.1. NC_011661.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	515635.Dtur_1278.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACK42556; ACK42556; Dtur_1278.
GeneID	7082762.
KEGG	dtu:Dtur_1278.
PATRIC	21811314. VBIDicTur93964_1318.
Phylogenomic databases
eggNOG	COG1057.
HOGENOM	HOG000262780.
KO	K00969.
OMA	IPPHKNT.
ProtClustDB	CLSK2409104.
Enzyme and pathway databases
BioCyc	DTUR515635:GH4F-1314-MONOMER.
UniPathway	UPA00253; UER00332.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_00244. NaMN_adenylyltr.
InterPro	IPR004821. Cyt_trans-like. IPR005248. NAMN_adtrnsfrase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR12039. PTHR12039. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit. TIGR00482. TIGR00482. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADD_DICTD

Accession

Primary (citable) accession number: B8E0B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program