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B8E032

- PROB_DICTD

UniProt

B8E032 - PROB_DICTD

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Protein
Glutamate 5-kinase
Gene
proB, Dtur_0834
Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101ATP By similarity
Binding sitei50 – 501Substrate By similarity
Binding sitei137 – 1371Substrate By similarity
Binding sitei149 – 1491Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1702ATP By similarity
Nucleotide bindingi208 – 2147ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. glutamate 5-kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDTUR515635:GH4F-839-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinase (EC:2.7.2.11)
Alternative name(s):
Gamma-glutamyl kinase
Short name:
GK
Gene namesi
Name:proB
Ordered Locus Names:Dtur_0834
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
ProteomesiUP000007719: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Glutamate 5-kinaseUniRule annotation
PRO_1000125227Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515635.Dtur_0834.

Structurei

3D structure databases

ProteinModelPortaliB8E032.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 35279PUA
Add
BLAST

Sequence similaritiesi

Contains 1 PUA domain.

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246369.
KOiK00931.
OMAiVEVVCQG.
OrthoDBiEOG6PGK7G.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8E032-1 [UniParc]FASTAAdd to Basket

« Hide

MNNWKRIVVK VGTSSITDGR GSPSGEKILS LVKECVKLIR ADKELVLVSS    50
GAIASGREII QKLSKRKDLP AKQALSAVGQ VRLMQYYSQL FSIFKQPIAQ 100
ILLTAEDLRD RKRYINISQT FETLLEEKII PIVNENDTVA VEEIKIGDND 150
TLSAKVACAI NADLLVILSD VEGLYSEDPN ISSNALLITD VYEIDESIEK 200
IAGPGKGTGG MFTKVQAAKI VTEAGIPMIL ARADVENILE RIVLKKEKVG 250
TFFYPSEKHL NKRKHWMLFM AKPEGRIYID DGAKDALLKR GKSLLPVGIK 300
KVEGEFTRGD TVSIFDLRGE EIARGITNYD SLELDKIKGK NTEEIRNILG 350
EDFYEEVIHR NNLVLTNRGD L 371
Length:371
Mass (Da):41,319
Last modified:March 3, 2009 - v1
Checksum:i0BF754F7BA8D0E77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001251 Genomic DNA. Translation: ACK42115.1.
RefSeqiYP_002352729.1. NC_011661.1.

Genome annotation databases

EnsemblBacteriaiACK42115; ACK42115; Dtur_0834.
GeneIDi7082786.
KEGGidtu:Dtur_0834.
PATRICi21810364. VBIDicTur93964_0873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001251 Genomic DNA. Translation: ACK42115.1 .
RefSeqi YP_002352729.1. NC_011661.1.

3D structure databases

ProteinModelPortali B8E032.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515635.Dtur_0834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK42115 ; ACK42115 ; Dtur_0834 .
GeneIDi 7082786.
KEGGi dtu:Dtur_0834.
PATRICi 21810364. VBIDicTur93964_0873.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246369.
KOi K00931.
OMAi VEVVCQG.
OrthoDBi EOG6PGK7G.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci DTUR515635:GH4F-839-MONOMER.

Family and domain databases

Gene3Di 2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SMARTi SM00359. PUA. 1 hit.
[Graphical view ]
SUPFAMi SSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS50890. PUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-1310 / DSM 6724.

Entry informationi

Entry nameiPROB_DICTD
AccessioniPrimary (citable) accession number: B8E032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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