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Protein

Thymidine kinase

Gene

tdk

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPUniRule annotation8
Nucleotide bindingi89 – 92ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciDTUR515635:G1GU5-808-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Dtur_0803
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001176661 – 198Thymidine kinaseAdd BLAST198

Proteomic databases

PRIDEiB8E001

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi515635.Dtur_0803

Structurei

3D structure databases

ProteinModelPortaliB8E001
SMRiB8E001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UGU Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
InParanoidiB8E001
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

B8E001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIVSGASGW IEVICGGMYS GKSEELIRRV RRAQIAKQKV QVFKHSLDIR
60 70 80 90 100
YDKDYVASHT GLKIEAIPVS SSADIERLVK DDTQVVAIEE GQFFDMGLVK
110 120 130 140 150
VCQRLADRGK RVIVAGLDQD FRGEPFGPMP YLMAVAEYVD KLHAICMKCG
160 170 180 190
NVASRTQRII DGKPAYYDDP IILVGAFETY EARCRHCHVV LRREEDEK
Length:198
Mass (Da):22,341
Last modified:March 3, 2009 - v1
Checksum:i05561B8A57BBDAB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA Translation: ACK42084.1
RefSeqiWP_012583168.1, NC_011661.1
YP_002352698.1, NC_011661.1

Genome annotation databases

EnsemblBacteriaiACK42084; ACK42084; Dtur_0803
GeneIDi7082095
KEGGidtu:Dtur_0803
PATRICifig|515635.4.peg.841

Similar proteinsi

Entry informationi

Entry nameiKITH_DICTD
AccessioniPrimary (citable) accession number: B8E001
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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