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B8E001 (KITH_DICTD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:Dtur_0803
OrganismDictyoglomus turgidum (strain Z-1310 / DSM 6724) [Reference proteome] [HAMAP]
Taxonomic identifier515635 [NCBI]
Taxonomic lineageBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Thymidine kinase HAMAP-Rule MF_00124
PRO_1000117666

Regions

Nucleotide binding16 – 238ATP By similarity
Nucleotide binding89 – 924ATP By similarity

Sites

Active site901Proton acceptor Potential
Metal binding1461Zinc By similarity
Metal binding1491Zinc By similarity
Metal binding1841Zinc By similarity
Metal binding1871Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
B8E001 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 05561B8A57BBDAB1

FASTA19822,341
        10         20         30         40         50         60 
MEIVSGASGW IEVICGGMYS GKSEELIRRV RRAQIAKQKV QVFKHSLDIR YDKDYVASHT 

        70         80         90        100        110        120 
GLKIEAIPVS SSADIERLVK DDTQVVAIEE GQFFDMGLVK VCQRLADRGK RVIVAGLDQD 

       130        140        150        160        170        180 
FRGEPFGPMP YLMAVAEYVD KLHAICMKCG NVASRTQRII DGKPAYYDDP IILVGAFETY 

       190 
EARCRHCHVV LRREEDEK 

« Hide

References

[1]"Complete sequence of Dictyoglomus turgidum DSM 6724."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-1310 / DSM 6724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001251 Genomic DNA. Translation: ACK42084.1.
RefSeqYP_002352698.1. NC_011661.1.

3D structure databases

ProteinModelPortalB8E001.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING515635.Dtur_0803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK42084; ACK42084; Dtur_0803.
GeneID7082095.
KEGGdtu:Dtur_0803.
PATRIC21810300. VBIDicTur93964_0841.

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076390.
KOK00857.
OMADHISEST.
OrthoDBEOG69D3J2.

Enzyme and pathway databases

BioCycDTUR515635:GH4F-808-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_DICTD
AccessionPrimary (citable) accession number: B8E001
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families