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B8DZX8

- DNLI_DICTD

UniProt

B8DZX8 - DNLI_DICTD

Protein

Probable DNA ligase

Gene

lig

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei243 – 2431ATPUniRule annotation
    Active sitei245 – 2451N6-AMP-lysine intermediateUniRule annotation
    Binding sitei250 – 2501ATPUniRule annotation
    Binding sitei265 – 2651ATPUniRule annotation
    Binding sitei295 – 2951ATPUniRule annotation
    Binding sitei335 – 3351ATPUniRule annotation
    Binding sitei410 – 4101ATPUniRule annotation
    Binding sitei416 – 4161ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDTUR515635:GH4F-781-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Dtur_0780
    OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
    Taxonomic identifieri515635 [NCBI]
    Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
    ProteomesiUP000007719: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Probable DNA ligasePRO_1000189919Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515635.Dtur_0780.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiGEFYPFQ.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8DZX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFGELAQYF EKIEKTTKRN EMMEILADLF KRVDKEEIEK IIYLLNGRVA    50
    PDYEKIEFGM SEKLVLRAMA LALKVPIFDL EKVYKEVGDL GELIIKYSQN 100
    EGKDLTVVET FNTLFEIANL SGEGSVDAKV NRLAFLINSL TPQGGKYLVR 150
    IVLGKLRLGV GEPTVMDALS FAKVKDKSLR PFIERAFNIT SDLGYVAKVF 200
    WEGGIEALKK IKVEVGKPIR MALAERVSKV EEIVKRLGKC AIEPKFDGFR 250
    CQIHKKENNV RIFSRNLEDN THMFPDLVEA VLKQFSDKNV IIEGEAISYN 300
    PETGEFYPFQ VTVQRKRKYN ISEMVELYPL QLFAFDILYL NGEDITSLPY 350
    IRRRQKLEEA ISEGEKIFVT KNIITNDPKE IQAFFEECIT EGLEGIVAKR 400
    LDAPYQAGIR NFNWIKLKRS YQGHLADTVD CVILGYFKGR GHRAKFGIGA 450
    LLVGVYDDER DLFKTVAKIG TGPTEEEWVR FREVLDEIKL ESKPNNVESL 500
    IEPDVWVEPK YVVVIQADEI TRSPVHTCGR ELDGLGYALR FPRVIGFVRE 550
    DKGPYDATTV KEILEMFRGQ KKEKVEEDSD NL 582
    Length:582
    Mass (Da):66,609
    Last modified:March 3, 2009 - v1
    Checksum:i8F52513B1C69AED3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001251 Genomic DNA. Translation: ACK42061.1.
    RefSeqiWP_012583146.1. NC_011661.1.
    YP_002352675.1. NC_011661.1.

    Genome annotation databases

    EnsemblBacteriaiACK42061; ACK42061; Dtur_0780.
    GeneIDi7082068.
    KEGGidtu:Dtur_0780.
    PATRICi21810246. VBIDicTur93964_0818.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001251 Genomic DNA. Translation: ACK42061.1 .
    RefSeqi WP_012583146.1. NC_011661.1.
    YP_002352675.1. NC_011661.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515635.Dtur_0780.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK42061 ; ACK42061 ; Dtur_0780 .
    GeneIDi 7082068.
    KEGGi dtu:Dtur_0780.
    PATRICi 21810246. VBIDicTur93964_0818.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi GEFYPFQ.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci DTUR515635:GH4F-781-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z-1310 / DSM 6724.

    Entry informationi

    Entry nameiDNLI_DICTD
    AccessioniPrimary (citable) accession number: B8DZX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3