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Protein

Probable DNA ligase

Gene

lig

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243ATPUniRule annotation1
Active sitei245N6-AMP-lysine intermediateUniRule annotation1
Binding sitei250ATPUniRule annotation1
Binding sitei265ATPUniRule annotation1
Binding sitei295ATPUniRule annotation1
Binding sitei335ATPUniRule annotation1
Binding sitei410ATPUniRule annotation1
Binding sitei416ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Dtur_0780
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi
  • UP000007719 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001899191 – 582Probable DNA ligaseAdd BLAST582

Interactioni

Protein-protein interaction databases

STRINGi515635.Dtur_0780.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TRG. Bacteria.
COG1793. LUCA.
HOGENOMiHOG000036008.
InParanoidiB8DZX8.
KOiK10747.
OMAiGMNIPTI.
OrthoDBiPOG091H09SJ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8DZX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFGELAQYF EKIEKTTKRN EMMEILADLF KRVDKEEIEK IIYLLNGRVA
60 70 80 90 100
PDYEKIEFGM SEKLVLRAMA LALKVPIFDL EKVYKEVGDL GELIIKYSQN
110 120 130 140 150
EGKDLTVVET FNTLFEIANL SGEGSVDAKV NRLAFLINSL TPQGGKYLVR
160 170 180 190 200
IVLGKLRLGV GEPTVMDALS FAKVKDKSLR PFIERAFNIT SDLGYVAKVF
210 220 230 240 250
WEGGIEALKK IKVEVGKPIR MALAERVSKV EEIVKRLGKC AIEPKFDGFR
260 270 280 290 300
CQIHKKENNV RIFSRNLEDN THMFPDLVEA VLKQFSDKNV IIEGEAISYN
310 320 330 340 350
PETGEFYPFQ VTVQRKRKYN ISEMVELYPL QLFAFDILYL NGEDITSLPY
360 370 380 390 400
IRRRQKLEEA ISEGEKIFVT KNIITNDPKE IQAFFEECIT EGLEGIVAKR
410 420 430 440 450
LDAPYQAGIR NFNWIKLKRS YQGHLADTVD CVILGYFKGR GHRAKFGIGA
460 470 480 490 500
LLVGVYDDER DLFKTVAKIG TGPTEEEWVR FREVLDEIKL ESKPNNVESL
510 520 530 540 550
IEPDVWVEPK YVVVIQADEI TRSPVHTCGR ELDGLGYALR FPRVIGFVRE
560 570 580
DKGPYDATTV KEILEMFRGQ KKEKVEEDSD NL
Length:582
Mass (Da):66,609
Last modified:March 3, 2009 - v1
Checksum:i8F52513B1C69AED3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA. Translation: ACK42061.1.
RefSeqiWP_012583146.1. NC_011661.1.
YP_002352675.1. NC_011661.1.

Genome annotation databases

EnsemblBacteriaiACK42061; ACK42061; Dtur_0780.
GeneIDi7082068.
KEGGidtu:Dtur_0780.
PATRICi21810246. VBIDicTur93964_0818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA. Translation: ACK42061.1.
RefSeqiWP_012583146.1. NC_011661.1.
YP_002352675.1. NC_011661.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi515635.Dtur_0780.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK42061; ACK42061; Dtur_0780.
GeneIDi7082068.
KEGGidtu:Dtur_0780.
PATRICi21810246. VBIDicTur93964_0818.

Phylogenomic databases

eggNOGiENOG4107TRG. Bacteria.
COG1793. LUCA.
HOGENOMiHOG000036008.
InParanoidiB8DZX8.
KOiK10747.
OMAiGMNIPTI.
OrthoDBiPOG091H09SJ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNLI_DICTD
AccessioniPrimary (citable) accession number: B8DZX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.