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B8DZX8

- DNLI_DICTD

UniProt

B8DZX8 - DNLI_DICTD

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Protein

Probable DNA ligase

Gene

lig

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei243 – 2431ATPUniRule annotation
Active sitei245 – 2451N6-AMP-lysine intermediateUniRule annotation
Binding sitei250 – 2501ATPUniRule annotation
Binding sitei265 – 2651ATPUniRule annotation
Binding sitei295 – 2951ATPUniRule annotation
Binding sitei335 – 3351ATPUniRule annotation
Binding sitei410 – 4101ATPUniRule annotation
Binding sitei416 – 4161ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDTUR515635:GH4F-781-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Dtur_0780
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
ProteomesiUP000007719: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Probable DNA ligasePRO_1000189919Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515635.Dtur_0780.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
InParanoidiB8DZX8.
KOiK10747.
OMAiGEFYPFQ.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8DZX8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFGELAQYF EKIEKTTKRN EMMEILADLF KRVDKEEIEK IIYLLNGRVA
60 70 80 90 100
PDYEKIEFGM SEKLVLRAMA LALKVPIFDL EKVYKEVGDL GELIIKYSQN
110 120 130 140 150
EGKDLTVVET FNTLFEIANL SGEGSVDAKV NRLAFLINSL TPQGGKYLVR
160 170 180 190 200
IVLGKLRLGV GEPTVMDALS FAKVKDKSLR PFIERAFNIT SDLGYVAKVF
210 220 230 240 250
WEGGIEALKK IKVEVGKPIR MALAERVSKV EEIVKRLGKC AIEPKFDGFR
260 270 280 290 300
CQIHKKENNV RIFSRNLEDN THMFPDLVEA VLKQFSDKNV IIEGEAISYN
310 320 330 340 350
PETGEFYPFQ VTVQRKRKYN ISEMVELYPL QLFAFDILYL NGEDITSLPY
360 370 380 390 400
IRRRQKLEEA ISEGEKIFVT KNIITNDPKE IQAFFEECIT EGLEGIVAKR
410 420 430 440 450
LDAPYQAGIR NFNWIKLKRS YQGHLADTVD CVILGYFKGR GHRAKFGIGA
460 470 480 490 500
LLVGVYDDER DLFKTVAKIG TGPTEEEWVR FREVLDEIKL ESKPNNVESL
510 520 530 540 550
IEPDVWVEPK YVVVIQADEI TRSPVHTCGR ELDGLGYALR FPRVIGFVRE
560 570 580
DKGPYDATTV KEILEMFRGQ KKEKVEEDSD NL
Length:582
Mass (Da):66,609
Last modified:March 3, 2009 - v1
Checksum:i8F52513B1C69AED3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA. Translation: ACK42061.1.
RefSeqiYP_002352675.1. NC_011661.1.

Genome annotation databases

EnsemblBacteriaiACK42061; ACK42061; Dtur_0780.
GeneIDi7082068.
KEGGidtu:Dtur_0780.
PATRICi21810246. VBIDicTur93964_0818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA. Translation: ACK42061.1 .
RefSeqi YP_002352675.1. NC_011661.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515635.Dtur_0780.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK42061 ; ACK42061 ; Dtur_0780 .
GeneIDi 7082068.
KEGGi dtu:Dtur_0780.
PATRICi 21810246. VBIDicTur93964_0818.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
InParanoidi B8DZX8.
KOi K10747.
OMAi GEFYPFQ.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci DTUR515635:GH4F-781-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-1310 / DSM 6724.

Entry informationi

Entry nameiDNLI_DICTD
AccessioniPrimary (citable) accession number: B8DZX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3