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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei143May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciDTUR515635:G1GU5-616-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Dtur_0615
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi
  • UP000007719 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002153891 – 257GTP cyclohydrolase FolE2Add BLAST257

Proteomic databases

PRIDEiB8DZH0

Interactioni

Protein-protein interaction databases

STRINGi515635.Dtur_0615

Structurei

3D structure databases

SMRiB8DZH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
InParanoidiB8DZH0
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

B8DZH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVQNERDY RGIYLRKVGI KNIHWPIKII TKSGEYQSTV ANIDISVDLR
60 70 80 90 100
EDLRGTHMSR FVEVLNGIDF LHPENLGKIL QEVREKLKAD SSHIKITFPY
110 120 130 140 150
FIFKKTPVSQ IASPNMIECV IEAELSKKLY MIIGVKVPIH TLCPCSKEIS
160 170 180 190 200
EYGAHNQRAI AEIYIKSKKL IWFEDLVEIA ERSASAPIYS LLKRPDEKYI
210 220 230 240 250
TETAYNNPKF VEDVVRDIVS ELEKEPKISW YRVEVTSFES IHNHNAFACV

EKGWIKK
Length:257
Mass (Da):29,786
Last modified:March 3, 2009 - v1
Checksum:iF662CF9D0E55F2BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA Translation: ACK41903.1
RefSeqiWP_012582988.1, NC_011661.1
YP_002352517.1, NC_011661.1

Genome annotation databases

EnsemblBacteriaiACK41903; ACK41903; Dtur_0615
GeneIDi7081655
KEGGidtu:Dtur_0615
PATRICifig|515635.4.peg.652

Similar proteinsi

Entry informationi

Entry nameiGCH4_DICTD
AccessioniPrimary (citable) accession number: B8DZH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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