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B8DZH0

- GCH4_DICTD

UniProt

B8DZH0 - GCH4_DICTD

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei143 – 1431May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciDTUR515635:GH4F-616-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Dtur_0615
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
ProteomesiUP000007719: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257GTP cyclohydrolase FolE2PRO_1000215389Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515635.Dtur_0615.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
InParanoidiB8DZH0.
KOiK09007.
OMAiLIWFEDL.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

B8DZH0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDVQNERDY RGIYLRKVGI KNIHWPIKII TKSGEYQSTV ANIDISVDLR
60 70 80 90 100
EDLRGTHMSR FVEVLNGIDF LHPENLGKIL QEVREKLKAD SSHIKITFPY
110 120 130 140 150
FIFKKTPVSQ IASPNMIECV IEAELSKKLY MIIGVKVPIH TLCPCSKEIS
160 170 180 190 200
EYGAHNQRAI AEIYIKSKKL IWFEDLVEIA ERSASAPIYS LLKRPDEKYI
210 220 230 240 250
TETAYNNPKF VEDVVRDIVS ELEKEPKISW YRVEVTSFES IHNHNAFACV

EKGWIKK
Length:257
Mass (Da):29,786
Last modified:March 3, 2009 - v1
Checksum:iF662CF9D0E55F2BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001251 Genomic DNA. Translation: ACK41903.1.
RefSeqiWP_012582988.1. NC_011661.1.
YP_002352517.1. NC_011661.1.

Genome annotation databases

EnsemblBacteriaiACK41903; ACK41903; Dtur_0615.
GeneIDi7081655.
KEGGidtu:Dtur_0615.
PATRICi21809914. VBIDicTur93964_0652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001251 Genomic DNA. Translation: ACK41903.1 .
RefSeqi WP_012582988.1. NC_011661.1.
YP_002352517.1. NC_011661.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515635.Dtur_0615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK41903 ; ACK41903 ; Dtur_0615 .
GeneIDi 7081655.
KEGGi dtu:Dtur_0615.
PATRICi 21809914. VBIDicTur93964_0652.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
InParanoidi B8DZH0.
KOi K09007.
OMAi LIWFEDL.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci DTUR515635:GH4F-616-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-1310 / DSM 6724.

Entry informationi

Entry nameiGCH4_DICTD
AccessioniPrimary (citable) accession number: B8DZH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3