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B8DZH0 (GCH4_DICTD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Dtur_0615
OrganismDictyoglomus turgidum (strain Z-1310 / DSM 6724) [Reference proteome] [HAMAP]
Taxonomic identifier515635 [NCBI]
Taxonomic lineageBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_1000215389

Sites

Site1431May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
B8DZH0 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: F662CF9D0E55F2BF

FASTA25729,786
        10         20         30         40         50         60 
MKDVQNERDY RGIYLRKVGI KNIHWPIKII TKSGEYQSTV ANIDISVDLR EDLRGTHMSR 

        70         80         90        100        110        120 
FVEVLNGIDF LHPENLGKIL QEVREKLKAD SSHIKITFPY FIFKKTPVSQ IASPNMIECV 

       130        140        150        160        170        180 
IEAELSKKLY MIIGVKVPIH TLCPCSKEIS EYGAHNQRAI AEIYIKSKKL IWFEDLVEIA 

       190        200        210        220        230        240 
ERSASAPIYS LLKRPDEKYI TETAYNNPKF VEDVVRDIVS ELEKEPKISW YRVEVTSFES 

       250 
IHNHNAFACV EKGWIKK 

« Hide

References

[1]"Complete sequence of Dictyoglomus turgidum DSM 6724."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-1310 / DSM 6724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001251 Genomic DNA. Translation: ACK41903.1.
RefSeqYP_002352517.1. NC_011661.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING515635.Dtur_0615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK41903; ACK41903; Dtur_0615.
GeneID7081655.
KEGGdtu:Dtur_0615.
PATRIC21809914. VBIDicTur93964_0652.

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMALIWFEDL.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycDTUR515635:GH4F-616-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCH4_DICTD
AccessionPrimary (citable) accession number: B8DZH0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways