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B8DZH0

- GCH4_DICTD

UniProt

B8DZH0 - GCH4_DICTD

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei143 – 1431May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciDTUR515635:GH4F-616-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Dtur_0615
    OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
    Taxonomic identifieri515635 [NCBI]
    Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
    ProteomesiUP000007719: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257GTP cyclohydrolase FolE2PRO_1000215389Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515635.Dtur_0615.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiLIWFEDL.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8DZH0-1 [UniParc]FASTAAdd to Basket

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    MKDVQNERDY RGIYLRKVGI KNIHWPIKII TKSGEYQSTV ANIDISVDLR    50
    EDLRGTHMSR FVEVLNGIDF LHPENLGKIL QEVREKLKAD SSHIKITFPY 100
    FIFKKTPVSQ IASPNMIECV IEAELSKKLY MIIGVKVPIH TLCPCSKEIS 150
    EYGAHNQRAI AEIYIKSKKL IWFEDLVEIA ERSASAPIYS LLKRPDEKYI 200
    TETAYNNPKF VEDVVRDIVS ELEKEPKISW YRVEVTSFES IHNHNAFACV 250
    EKGWIKK 257
    Length:257
    Mass (Da):29,786
    Last modified:March 3, 2009 - v1
    Checksum:iF662CF9D0E55F2BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001251 Genomic DNA. Translation: ACK41903.1.
    RefSeqiYP_002352517.1. NC_011661.1.

    Genome annotation databases

    EnsemblBacteriaiACK41903; ACK41903; Dtur_0615.
    GeneIDi7081655.
    KEGGidtu:Dtur_0615.
    PATRICi21809914. VBIDicTur93964_0652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001251 Genomic DNA. Translation: ACK41903.1 .
    RefSeqi YP_002352517.1. NC_011661.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515635.Dtur_0615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK41903 ; ACK41903 ; Dtur_0615 .
    GeneIDi 7081655.
    KEGGi dtu:Dtur_0615.
    PATRICi 21809914. VBIDicTur93964_0652.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi LIWFEDL.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci DTUR515635:GH4F-616-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Dictyoglomus turgidum DSM 6724."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Mead D.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z-1310 / DSM 6724.

    Entry informationi

    Entry nameiGCH4_DICTD
    AccessioniPrimary (citable) accession number: B8DZH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3