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Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119 – 120Important for bifunctional activityUniRule annotation2
Binding sitei122dCTPUniRule annotation1
Active sitei132Proton donor/acceptorUniRule annotation1
Binding sitei151dCTPUniRule annotation1
Binding sitei165dCTPUniRule annotation1
Binding sitei172dCTPUniRule annotation1
Binding sitei176dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 109dCTP bindingUniRule annotation6
Nucleotide bindingi130 – 132dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciDTUR515635:G1GU5-52-MONOMER
UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:Dtur_0052
OrganismiDictyoglomus turgidum (strain Z-1310 / DSM 6724)
Taxonomic identifieri515635 [NCBI]
Taxonomic lineageiBacteriaDictyoglomiDictyoglomalesDictyoglomaceaeDictyoglomus
Proteomesi
  • UP000007719 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001898271 – 194dCTP deaminase, dUMP-formingAdd BLAST194

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi515635.Dtur_0052

Structurei

3D structure databases

ProteinModelPortaliB8DYK8
SMRiB8DYK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228601
InParanoidiB8DYK8
KOiK01494
OMAiGWIDAGF
OrthoDBiPOG091H021I

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

B8DYK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDKDIKK YLEERKLVIH PIDDPQKQIQ PSSVDLRLGN SFLHFKVEGR
60 70 80 90 100
AYIDPTKDNP QDLMEIIEIE EGKPFFLRPG EFVLGTTIET VKLPDDLVAR
110 120 130 140 150
VDGRSSLGRL GIIVHATAGY VDPGFCGQIT LELSNINRVP VALYPGMRIC
160 170 180 190
QISFYKLTSP AETPYYKKAG SKYHNQKGPT ASKLNIDFCV KEDK
Length:194
Mass (Da):21,824
Last modified:March 3, 2009 - v1
Checksum:i9B7774AC81B38591
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001251 Genomic DNA Translation: ACK41390.1
RefSeqiWP_012582476.1, NC_011661.1
YP_002352004.1, NC_011661.1

Genome annotation databases

EnsemblBacteriaiACK41390; ACK41390; Dtur_0052
GeneIDi7082319
KEGGidtu:Dtur_0052
PATRICifig|515635.4.peg.53

Similar proteinsi

Entry informationi

Entry nameiDCDB_DICTD
AccessioniPrimary (citable) accession number: B8DYK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health