Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B8DWQ9

- B8DWQ9_BIFA0

UniProt

B8DWQ9 - B8DWQ9_BIFA0

Protein

Diaminopimelate decarboxylase

Gene

lysA

Organism
Bifidobacterium animalis subsp. lactis (strain AD011)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.UniRule annotation

    Catalytic activityi

    Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei330 – 3301Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei375 – 3751SubstrateUniRule annotation
    Binding sitei425 – 4251SubstrateUniRule annotation
    Binding sitei429 – 4291SubstrateUniRule annotation
    Binding sitei457 – 4571SubstrateUniRule annotation
    Binding sitei486 – 4861Pyridoxal phosphateUniRule annotation
    Binding sitei486 – 4861SubstrateUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate decarboxylase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBANI442563:GHG0-612-MONOMER.
    UniPathwayiUPA00034; UER00027.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
    Short name:
    DAP decarboxylaseUniRule annotation
    Short name:
    DAPDCUniRule annotation
    Gene namesi
    Name:lysAUniRule annotationImported
    Ordered Locus Names:BLA_0617Imported
    OrganismiBifidobacterium animalis subsp. lactis (strain AD011)Imported
    Taxonomic identifieri442563 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000002456: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei72 – 721N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi442563.BLA_0617.

    Structurei

    3D structure databases

    ProteinModelPortaliB8DWQ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni372 – 3754Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0019.
    HOGENOMiHOG000045071.
    KOiK01586.
    OMAiDFRARCR.
    OrthoDBiEOG6Z9B18.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 2 hits.
    HAMAPiMF_02120. LysA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002986. DAP_deCOOHase_LysA.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 2 hits.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 2 hits.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8DWQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAISPIWPAD TARNSNGELT FHGITASTLL DEFGSPLYVL DLDEVRARAS    50
    HFVKAAAHAF TNNTTHVSYA AKAFLSKEMA RIVTEEGMFV DTCTLGEMKI 100
    ALAAGVPGRR LVLHGNNKSD EEIELAIAEG FSKIVIDSPD EPARIAAIAE 150
    RLGKRARVML RVTSGIHAGG HEYVSTAHED QKFGVALLPA GADTEIVDNI 200
    DQLQDVSPAA TNALVHETEL ERGGETKQQA DRQLRYDVRY PYDLNAADVT 250
    EGDRLLAAAM ELVANGPAIA VLREIAKYGN LELVGVHSHI GSNIHDAEAF 300
    IQAAKRMMLL RKTFYATNAY TLPEVDLGGG YSVAYTDDED RMDVDRELGR 350
    LADAVSKTNR LLGMPAPIIS FEPGRWIVAP AGVTLYRVGT VKTVQLGDGF 400
    TNNAGERIRE RAYISVDGGM SDNIRPALYD AKYTAILANR ESAEPAKLSR 450
    VVGIHCESGD IVVNEANLPA DVHRGDILAV PVTGAYGRSM ASNYNMALIP 500
    AVVGIDGHGA HVMMRRQTID DLLALDVSE 529
    Length:529
    Mass (Da):57,114
    Last modified:March 3, 2009 - v1
    Checksum:iDF015C5601DA58D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001213 Genomic DNA. Translation: ACL28910.1.
    RefSeqiYP_002469486.1. NC_011835.1.

    Genome annotation databases

    EnsemblBacteriaiACL28910; ACL28910; BLA_0617.
    GeneIDi7264024.
    KEGGibla:BLA_0617.
    PATRICi21104119. VBIBifAni98964_0648.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001213 Genomic DNA. Translation: ACL28910.1 .
    RefSeqi YP_002469486.1. NC_011835.1.

    3D structure databases

    ProteinModelPortali B8DWQ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 442563.BLA_0617.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL28910 ; ACL28910 ; BLA_0617 .
    GeneIDi 7264024.
    KEGGi bla:BLA_0617.
    PATRICi 21104119. VBIBifAni98964_0648.

    Phylogenomic databases

    eggNOGi COG0019.
    HOGENOMi HOG000045071.
    KOi K01586.
    OMAi DFRARCR.
    OrthoDBi EOG6Z9B18.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00027 .
    BioCyci BANI442563:GHG0-612-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 2 hits.
    HAMAPi MF_02120. LysA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002986. DAP_deCOOHase_LysA.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 2 hits.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 2 hits.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
      Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
      J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AD011Imported.

    Entry informationi

    Entry nameiB8DWQ9_BIFA0
    AccessioniPrimary (citable) accession number: B8DWQ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3