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B8DVV8

- PNP_BIFA0

UniProt

B8DVV8 - PNP_BIFA0

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Bifidobacterium animalis subsp. lactis (strain AD011)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi521 – 5211MagnesiumUniRule annotation
    Metal bindingi527 – 5271MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciBANI442563:GHG0-307-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:BLA_0307
    OrganismiBifidobacterium animalis subsp. lactis (strain AD011)
    Taxonomic identifieri442563 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000002456: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Polyribonucleotide nucleotidyltransferasePRO_1000185723Add
    BLAST

    Proteomic databases

    PRIDEiB8DVV8.

    Interactioni

    Protein-protein interaction databases

    STRINGi442563.BLA_0307.

    Structurei

    3D structure databases

    ProteinModelPortaliB8DVV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini587 – 64660KHUniRule annotationAdd
    BLAST
    Domaini658 – 73073S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiTIAGKQD.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8DVV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGPEIKAVE AVIDNGSFGR RTVRFETGRL ARQADGAVAA YLDDDSMVLS    50
    TTTAGSSPKE NYDFFPLTVD VEEKMYAAGK IPGSFFRREG RPSSEAILAC 100
    RIIDRPLRPL FPHTLRNEVQ VVETVLAVNP EDSYDVLALN AASASTLISG 150
    LPFTGPVGGV RLALIDGQWV AFPRWSERER AVFEIVVAGR VVESGDVAIA 200
    MIEAGAGKNA WNLIYDEGQQ KPDEEVVAGG LEAAKPFIKV LCDAQNELKR 250
    LAAKETREFT LFPEYTDDLY NRIDEIAHAD LDEALSIAEK LPRQERIAEI 300
    KQRVKDTLSV EFTDMDEMEK DKEIGNAFKE LQRQIVRRRI LTQDYRIDGR 350
    GLRDIRTLSA EIDVVPRVHG SALFQRGETQ ILGITTLNML KMEQQIDALS 400
    GPTTKRYMHN YEMPPYSTGE TGRVGSPKRR EIGHGALAEK AIVPVLPSRE 450
    EFPYAIRQVS EAIGSNGSTS MGSVCASTLS LLAAGVPLKA PVAGIAMGLV 500
    SGDVDGQHIY KTLTDILGAE DAFGDMDFKV AGTADFITAL QLDTKLDGIP 550
    ADVLAGALKQ AHEARKTILE VINECIDGPA EMSPFAPRII TTTVPVDKIG 600
    EVIGPKGKMI NQIQEDTGAE IAIEDDGTVY ISSEGGEAAE KAKQIIDEIA 650
    NPHVPQAGET YKGTVVKTTS FGAFVNLTPG IDGLLHISQI RNLADGQRID 700
    AVEDVLKEGD SVEVVVQGVD DRGKISLAIP GFENQENNAG GRRSDDRPRR 750
    DDRRHSDDRR RDDRPRRRSD DRDRDYDDRP RRRRDYDDDR DYDDRPRRRS 800
    HRDYDDDRDY DDRPRRSDRR RDYDDDRPRR RRNDDRNPRY VADENYDEYR 850
    EGREVRHERP RRRVRRDFDP FDD 873
    Length:873
    Mass (Da):97,727
    Last modified:March 3, 2009 - v1
    Checksum:i7C8231CD6473C758
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001213 Genomic DNA. Translation: ACL28609.1.
    RefSeqiYP_002469185.1. NC_011835.1.

    Genome annotation databases

    EnsemblBacteriaiACL28609; ACL28609; BLA_0307.
    GeneIDi7263718.
    KEGGibla:BLA_0307.
    PATRICi21103451. VBIBifAni98964_0329.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001213 Genomic DNA. Translation: ACL28609.1 .
    RefSeqi YP_002469185.1. NC_011835.1.

    3D structure databases

    ProteinModelPortali B8DVV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 442563.BLA_0307.

    Proteomic databases

    PRIDEi B8DVV8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL28609 ; ACL28609 ; BLA_0307 .
    GeneIDi 7263718.
    KEGGi bla:BLA_0307.
    PATRICi 21103451. VBIBifAni98964_0329.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi TIAGKQD.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci BANI442563:GHG0-307-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
      Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
      J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AD011.

    Entry informationi

    Entry nameiPNP_BIFA0
    AccessioniPrimary (citable) accession number: B8DVV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3