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B8DVV8

- PNP_BIFA0

UniProt

B8DVV8 - PNP_BIFA0

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, BLA_0307
Organism
Bifidobacterium animalis subsp. lactis (strain AD011)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi521 – 5211Magnesium By similarity
Metal bindingi527 – 5271Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBANI442563:GHG0-307-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:BLA_0307
OrganismiBifidobacterium animalis subsp. lactis (strain AD011)
Taxonomic identifieri442563 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002456: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000185723Add
BLAST

Proteomic databases

PRIDEiB8DVV8.

Interactioni

Protein-protein interaction databases

STRINGi442563.BLA_0307.

Structurei

3D structure databases

ProteinModelPortaliB8DVV8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini587 – 64660KH
Add
BLAST
Domaini658 – 73073S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8DVV8-1 [UniParc]FASTAAdd to Basket

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MEGPEIKAVE AVIDNGSFGR RTVRFETGRL ARQADGAVAA YLDDDSMVLS    50
TTTAGSSPKE NYDFFPLTVD VEEKMYAAGK IPGSFFRREG RPSSEAILAC 100
RIIDRPLRPL FPHTLRNEVQ VVETVLAVNP EDSYDVLALN AASASTLISG 150
LPFTGPVGGV RLALIDGQWV AFPRWSERER AVFEIVVAGR VVESGDVAIA 200
MIEAGAGKNA WNLIYDEGQQ KPDEEVVAGG LEAAKPFIKV LCDAQNELKR 250
LAAKETREFT LFPEYTDDLY NRIDEIAHAD LDEALSIAEK LPRQERIAEI 300
KQRVKDTLSV EFTDMDEMEK DKEIGNAFKE LQRQIVRRRI LTQDYRIDGR 350
GLRDIRTLSA EIDVVPRVHG SALFQRGETQ ILGITTLNML KMEQQIDALS 400
GPTTKRYMHN YEMPPYSTGE TGRVGSPKRR EIGHGALAEK AIVPVLPSRE 450
EFPYAIRQVS EAIGSNGSTS MGSVCASTLS LLAAGVPLKA PVAGIAMGLV 500
SGDVDGQHIY KTLTDILGAE DAFGDMDFKV AGTADFITAL QLDTKLDGIP 550
ADVLAGALKQ AHEARKTILE VINECIDGPA EMSPFAPRII TTTVPVDKIG 600
EVIGPKGKMI NQIQEDTGAE IAIEDDGTVY ISSEGGEAAE KAKQIIDEIA 650
NPHVPQAGET YKGTVVKTTS FGAFVNLTPG IDGLLHISQI RNLADGQRID 700
AVEDVLKEGD SVEVVVQGVD DRGKISLAIP GFENQENNAG GRRSDDRPRR 750
DDRRHSDDRR RDDRPRRRSD DRDRDYDDRP RRRRDYDDDR DYDDRPRRRS 800
HRDYDDDRDY DDRPRRSDRR RDYDDDRPRR RRNDDRNPRY VADENYDEYR 850
EGREVRHERP RRRVRRDFDP FDD 873
Length:873
Mass (Da):97,727
Last modified:March 3, 2009 - v1
Checksum:i7C8231CD6473C758
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001213 Genomic DNA. Translation: ACL28609.1.
RefSeqiYP_002469185.1. NC_011835.1.

Genome annotation databases

EnsemblBacteriaiACL28609; ACL28609; BLA_0307.
GeneIDi7263718.
KEGGibla:BLA_0307.
PATRICi21103451. VBIBifAni98964_0329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001213 Genomic DNA. Translation: ACL28609.1 .
RefSeqi YP_002469185.1. NC_011835.1.

3D structure databases

ProteinModelPortali B8DVV8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 442563.BLA_0307.

Proteomic databases

PRIDEi B8DVV8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL28609 ; ACL28609 ; BLA_0307 .
GeneIDi 7263718.
KEGGi bla:BLA_0307.
PATRICi 21103451. VBIBifAni98964_0329.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci BANI442563:GHG0-307-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
    Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
    J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AD011.

Entry informationi

Entry nameiPNP_BIFA0
AccessioniPrimary (citable) accession number: B8DVV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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