B8DV60 (ARAA_BIFA0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	BLA_0058

Organism

Bifidobacterium animalis subsp. lactis (strain AD011) [Complete proteome] [HAMAP]

Taxonomic identifier

442563 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	L-arabinose isomerase HAMAP MF_00519		PRO_1000146224
Sites
	Metal binding	308	1	Manganese By similarity
	Metal binding	335	1	Manganese By similarity
	Metal binding	352	1	Manganese By similarity
	Metal binding	453	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8DV60 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: EF64A716269F520D	FASTA	505	55,987
	10 20 30 40 50 60 MAMENPFEGK EIWFGVGSQD LYGEEALRQV AQQSAEIVDS LNASGRIPVK LVLKPTLKSS 70 80 90 100 110 120 DGVRRFMVDA SADDSCIGVI TWMHTFSPAK MWIRGLEALR KPLLQLNTQH HFEIPWETID 130 140 150 160 170 180 MDFMNLNQAA HGDREYGYIV TRLGIPRKIV VGHYTDPAVA DKIGVWARAC AGWQASNTMN 190 200 210 220 230 240 VMRWGDNMRN VAVTEGDKTE AERVFGASIN TWAVNELVAA YDAVKENQIK DLIEDYKAKY 250 260 270 280 290 300 EIAPELLDKD YDSLFIAARE ECAMVNMMRA NGCTAGVDNF EDLGALPQLP GVGPQRFPSE 310 320 330 340 350 360 YGWGFSAEGD WKTAVLVRIG AVMGYGLEGG ASLMEDYSYN FTPGNEMIMG SHMLEVSPSV 370 380 390 400 410 420 GTIAKPRLEI HPLGIGGKAD PVRLVFTVAP KKDAVVVSLA DVRTRFRMLM NVVDVVEPLG 430 440 450 460 470 480 SLDKLPCARA LWKPEPNLEI SAECWLRAGG SHHTCMTTSV GREAWEDFAR IAGVELAAID 490 500 AETTPREFER ELEIEDVFHE LANRH

References

[1]

"Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011." Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K. J. Bacteriol. 191:678-679(2009) [PubMed: 19011029] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AD011.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001213 Genomic DNA. Translation: ACL28361.1.
RefSeq	YP_002468937.1. NC_011835.1.
3D structure databases
ProteinModelPortal	B8DV60.
ModBase	Search...
Protein-protein interaction databases
STRING	B8DV60.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7263469.
GenomeReviews	Gene locus BLA_0058 in contig CP001213_GR.
KEGG	bla:BLA_0058.
PATRIC	21102900. VBIBifAni98964_0063.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297198.
OMA	EVCPTIA.
ProtClustDB	PRK02929.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_BIFA0

Accession

Primary (citable) accession number: B8DV60

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program