Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Xanthine phosphoribosyltransferase

Gene

xpt

Organism
Bifidobacterium animalis subsp. lactis (strain AD011)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (xpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei27 – 271XanthineUniRule annotation
Binding sitei157 – 1571XanthineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciBANI442563:GHG0-1452-MONOMER.
UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Short name:
XPRTaseUniRule annotation
Gene namesi
Name:xptUniRule annotation
Ordered Locus Names:BLA_1460
OrganismiBifidobacterium animalis subsp. lactis (strain AD011)
Taxonomic identifieri442563 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000002456 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Xanthine phosphoribosyltransferasePRO_1000164447Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8DUR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 13355-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036777.
KOiK03816.
OMAiHQIDPEL.
OrthoDBiEOG6GTZNX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

B8DUR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQELEERIRE QGVVKPGNVL KVDAFLNHQC DVRLFDHMGA AWAEHFNNKH
60 70 80 90 100
ITKILTIEAS GIGIACVAAT HFDDVPVVFA KKAQSINLDG EQYVTHVYSF
110 120 130 140 150
TKQKEFPVIV SKKYLNAGDR VLLIDDFLAN GKALNGLIEL CESAGAIVEG
160 170 180 190
IGIAIEKGFQ GGGDALREAG YDLDSLAIVE SMDAETGAIE FRH
Length:193
Mass (Da):21,073
Last modified:March 3, 2009 - v1
Checksum:i272C76F5FEEBC433
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001213 Genomic DNA. Translation: ACL29743.1.
RefSeqiWP_004217806.1. NC_011835.1.

Genome annotation databases

EnsemblBacteriaiACL29743; ACL29743; BLA_1460.
GeneIDi7264864.
KEGGibla:BLA_1460.
PATRICi21105938. VBIBifAni98964_1527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001213 Genomic DNA. Translation: ACL29743.1.
RefSeqiWP_004217806.1. NC_011835.1.

3D structure databases

ProteinModelPortaliB8DUR4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL29743; ACL29743; BLA_1460.
GeneIDi7264864.
KEGGibla:BLA_1460.
PATRICi21105938. VBIBifAni98964_1527.

Phylogenomic databases

HOGENOMiHOG000036777.
KOiK03816.
OMAiHQIDPEL.
OrthoDBiEOG6GTZNX.

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.
BioCyciBANI442563:GHG0-1452-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
    Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
    J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AD011.

Entry informationi

Entry nameiXPT_BIFA0
AccessioniPrimary (citable) accession number: B8DUR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 11, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.