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B8DUF9 (UPPP_BIFA0) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:BLA_1353
OrganismBifidobacterium animalis subsp. lactis (strain AD011) [Complete proteome] [HAMAP]
Taxonomic identifier442563 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148801

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane198 – 21821Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane263 – 28321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B8DUF9 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 3C13781C247D6E4F

FASTA29531,934
        10         20         30         40         50         60 
MNFFQAIFLG LVQALTEYLP VSSSAHVRIV GDLMLGGDPG AAFTAIIQIG TELAVLLYFR 

        70         80         90        100        110        120 
RDIWNILKSW CLCLAGKEGK DRASRFGAHN KDARLGWYII IATIPILIAG VLFQHAIETT 

       130        140        150        160        170        180 
LRNLWITVAM LFIFGVILWI VDDRARQVKT LDDMNTKDAI WFGIGQMLAL IPGVSRSGGT 

       190        200        210        220        230        240 
ITFGRAMGYK REAAVRAAFL MAIPAVFGAG ILEAVKAIKD VNADAMFPGW GATIAATVVA 

       250        260        270        280        290 
FVVGYIVIIG FLKFVSTYSY KAFAIYRIAL AIIVAILLLC GVLSPLEGIP VSGNA 

« Hide

References

[1]"Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AD011.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001213 Genomic DNA. Translation: ACL29638.1.
RefSeqYP_002470214.1. NC_011835.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING442563.BLA_1353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL29638; ACL29638; BLA_1353.
GeneID7264757.
KEGGbla:BLA_1353.
PATRIC21105714. VBIBifAni98964_1416.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK12554.

Enzyme and pathway databases

BioCycBANI442563:GHG0-1345-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_BIFA0
AccessionPrimary (citable) accession number: B8DUF9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families