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B8DUF9

- UPPP_BIFA0

UniProt

B8DUF9 - UPPP_BIFA0

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, BLA_1353
Organism
Bifidobacterium animalis subsp. lactis (strain AD011)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBANI442563:GHG0-1345-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:BLA_1353
OrganismiBifidobacterium animalis subsp. lactis (strain AD011)
Taxonomic identifieri442563 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002456: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Transmembranei97 – 11721Helical; Reviewed prediction
Add
BLAST
Transmembranei121 – 14121Helical; Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Transmembranei263 – 28321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Undecaprenyl-diphosphataseUniRule annotation
PRO_1000148801Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi442563.BLA_1353.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiIEGPFRD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B8DUF9-1 [UniParc]FASTAAdd to Basket

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MNFFQAIFLG LVQALTEYLP VSSSAHVRIV GDLMLGGDPG AAFTAIIQIG    50
TELAVLLYFR RDIWNILKSW CLCLAGKEGK DRASRFGAHN KDARLGWYII 100
IATIPILIAG VLFQHAIETT LRNLWITVAM LFIFGVILWI VDDRARQVKT 150
LDDMNTKDAI WFGIGQMLAL IPGVSRSGGT ITFGRAMGYK REAAVRAAFL 200
MAIPAVFGAG ILEAVKAIKD VNADAMFPGW GATIAATVVA FVVGYIVIIG 250
FLKFVSTYSY KAFAIYRIAL AIIVAILLLC GVLSPLEGIP VSGNA 295
Length:295
Mass (Da):31,934
Last modified:March 3, 2009 - v1
Checksum:i3C13781C247D6E4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001213 Genomic DNA. Translation: ACL29638.1.
RefSeqiYP_002470214.1. NC_011835.1.

Genome annotation databases

EnsemblBacteriaiACL29638; ACL29638; BLA_1353.
GeneIDi7264757.
KEGGibla:BLA_1353.
PATRICi21105714. VBIBifAni98964_1416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001213 Genomic DNA. Translation: ACL29638.1 .
RefSeqi YP_002470214.1. NC_011835.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 442563.BLA_1353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL29638 ; ACL29638 ; BLA_1353 .
GeneIDi 7264757.
KEGGi bla:BLA_1353.
PATRICi 21105714. VBIBifAni98964_1416.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi IEGPFRD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BANI442563:GHG0-1345-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
    Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
    J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AD011.

Entry informationi

Entry nameiUPPP_BIFA0
AccessioniPrimary (citable) accession number: B8DUF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi