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B8DTT6

- PUR5_BIFA0

UniProt

B8DTT6 - PUR5_BIFA0

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bifidobacterium animalis subsp. lactis (strain AD011)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBANI442563:GHG0-1120-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:BLA_1127
    OrganismiBifidobacterium animalis subsp. lactis (strain AD011)
    Taxonomic identifieri442563 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000002456: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000148268Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi442563.BLA_1127.

    Structurei

    3D structure databases

    ProteinModelPortaliB8DTT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiTKVMLAQ.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8DTT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQAYENAGV SVEAGYEVVK RIKSHVARTN RPGVVSGIGG FGGLFDLASL    50
    GYNEPVLISG TDGVGTKLVI AKLMDKHDTI GIDCVAMCVN DVVAQGAQPL 100
    FFLDYIACGK NDPAVLEQVV SGVADGCVQA GAALIGGETA EMPGMYDEDE 150
    YDLAGFTVGC VERSKIVDGS TIEAGDVLIG LPSTGVHSNG FSLVRKALFE 200
    QAGYTVHTRL PELDDRELGD VLLTPTKIYV KALMPLFEAN LVRGVAHITG 250
    GGFIENVPRM LPEGLAASIE LGSWPVPPIF DVIEKAGDVD HMEMYNIFNM 300
    GLGMVVAIRP DRVDEAMNLL EHAGEKAYRV GHVIEQVNER VDLA 344
    Length:344
    Mass (Da):36,617
    Last modified:March 3, 2009 - v1
    Checksum:i7D8CBF4B7771D930
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001213 Genomic DNA. Translation: ACL29415.1.
    RefSeqiYP_002469991.1. NC_011835.1.

    Genome annotation databases

    EnsemblBacteriaiACL29415; ACL29415; BLA_1127.
    GeneIDi7264532.
    KEGGibla:BLA_1127.
    PATRICi21105219. VBIBifAni98964_1181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001213 Genomic DNA. Translation: ACL29415.1 .
    RefSeqi YP_002469991.1. NC_011835.1.

    3D structure databases

    ProteinModelPortali B8DTT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 442563.BLA_1127.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL29415 ; ACL29415 ; BLA_1127 .
    GeneIDi 7264532.
    KEGGi bla:BLA_1127.
    PATRICi 21105219. VBIBifAni98964_1181.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi TKVMLAQ.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci BANI442563:GHG0-1120-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
      Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
      J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AD011.

    Entry informationi

    Entry nameiPUR5_BIFA0
    AccessioniPrimary (citable) accession number: B8DTT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3